久强脑立清对自发性高血压大鼠血浆血栓素A_2和前列环素水平的影响  

Effect of Jiuqiang Naoliqing on the TXA_2 and PGI_2 level in spontaneous hypertension rat plasma

作　　者：孔祥英[1] 左萍萍[1] 李志猛[2] 段金虹[1] 孔令娜[1] 戴顺龄[1] 

机构地区：[1]中国医学科学院,中国协和医科大学基础医学院药理系,北京市100005 [2]北京同仁堂股份有限公司科学研究所,北京市100011

出　　处：《中国康复理论与实践》2004年第9期518-519,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨久强脑立清 (JNQ )对自发性高血压大鼠 (SHR)血浆血栓素A2 (TXA2 )和前列环素 (PGI2 )水平的影响。方法设立JNQ低、中、高剂量 3个组 ,剂量分别为 0 13 3 g/kg、0 2 65 g/kg和 0 5 3 0g/kg ,SHR和正常Wistar大鼠对照组给予 1%羧甲基纤维素溶媒对照 ,分别灌胃给药 5周后 ,分离血浆 ,用放免法测定血浆中TXA2 和PGI2 的稳定代谢产物TXB2 和 6 keto PGF1α的水平。结果SHR血浆TXB2 及TXB2 /6 keto PGF1α(T/P)值明显上升 (P <0 0 1) ,PGI2 无明显变化 (P >0 0 5 )。经JNQ3种剂量治疗 5周后 ,SHR的血浆TXB2 均显著下降 ,并呈明显的剂量依赖关系 ,高剂量组SHR血浆 6 keto PGF1α水平也有明显提高 ,各治疗组T/P比值均下降。结论JNQ对SHR血浆TXA2 /PGI2ObjectiveTo investigate the effect of Jiuqiang Naoliqing(JNQ) on the TXA 2 and PGI 2 level in spontaneous hypertension rat (SHR) plasma.MethodsThe plasma was separated after the SHR and Wistar rats were treated with JNQ at the dose of 0 133 g/kg,0 265 g/kg,0 530 g/kg and 1% carboxymethyl cellulose respectively for 5 weeks. The level of TXB 2 and 6 keto PGF 1α ,stable metabolin of TXA 2 and PGI 2,in SHR plasma was tested by radioimmunoassay.ResultsThe level of TXB 2 and the ratio of TXB 2/6 keto PGF 1α (T/P) in SHR plasma increased significantly(P<0 01),and there was no significant difference in the concentration of 6 keto PGF 1α between Wistar rats and SHR plasma(P>0 05). JNQ could increase the generation of 6 keto PGF 1α and decrease the level of TXB 2 and T/P in SHR plasma after treated with different dosages for 5 weeks.ConclusionJNQ may improve the balance between TXA 2 and PGI 2 in SHR plasma.

关 键 词：久强脑立清 自发性高血压大鼠(SHR) 血栓素A2 前列环素 

分 类 号：R285.5[医药卫生—中药学]