久强脑立清对昆明种小鼠行为的影响  

Effect of Jiuqiang Naoliqing on the behavior of Kunming mice

作　　者：徐海峰[1] 李志猛[2] 杨楠[1] 左萍萍[1] 岳赟[1] 牟亮[1] 

机构地区：[1]中国医学科学院,中国协和医科大学基础医学院药理系,北京市100005 [2]北京同仁堂股份有限公司科学研究所,北京市100011

出　　处：《中国康复理论与实践》2004年第9期524-525,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的评价久强脑立清 (JNQ)对昆明种小鼠行为的作用。方法采用自发运动、Morris水迷宫、转杆实验、对咖啡因引起的兴奋作用、戊巴比妥钠睡眠时间、戊巴比妥钠阈下催眠剂量实验以及对戊四唑引起的惊厥作用等方法对小鼠的行为进行评价。结果和对照组相比 ,JNQ低剂量组可增加小鼠自发运动 ,中、高剂量组可以延长小鼠在转杆上的运动时间 ;脑立清各剂量组可以延长戊巴比妥钠睡眠时间 ,增加戊巴比妥钠阈下催眠剂量时的睡眠百分数 ,并拮抗咖啡因的兴奋作用。结论JNQ对昆明种小鼠具有镇静、安眠作用 。ObjectiveTo observe the effect of Jiuqiang Naoliqing (JNQ) on the behavior of Kunming mice.MethodsSpontaneous movement, Morris Water Maze, Rotarod, anti caffeine test, sleeping time of pentobarbital sodium, subthreshold dose of pentobarbital sodium, and anti pentylene tetrazol test were adopted to evaluate the behavioral changes. ResultsCompared with the control group, the low dose of JNQ can increase spontaneous movement of the mice, the middle and high dose of JNQ can increase time on the rotating rods. JNQ can also increase sleeping time of pentobarbital sodium test and percent of falling asleep in subthreshold dose of pentobarbital sodium test, as well as antagonize caffeine's effect on mice. ConclusionJNQ can also do sedative and hypnotic effect on Kunming mice as well as improve their ability of balance and coordination.

关 键 词：久强脑立清 行为 小鼠 

分 类 号：R285.5[医药卫生—中药学]