脂筏与精子膜信号传导  

Lipid rafts and the signaling in sperm membrane

作　　者：周思畅[1] 袁玉英[1] 石其贤[1] 

机构地区：[1]浙江省医学科学院,杭州310013

出　　处：《生命科学》2004年第5期271-274,共4页Chinese Bulletin of Life Sciences

基　　金：国家重点基础研究发展规划项目(G1999055902);国家自然科学基金项目(30270513)

摘　　要：脂筏是细胞膜内由特殊脂质与蛋白质构成的微域。小窝是脂筏的一种形式,小窝标记蛋白有小窝蛋白和小窝舟蛋白。脂筏或小窝与生物信号传导、细胞蛋白转运和胆固醇平衡有关。最近实验证实哺乳动物精子膜具有脂筏结构,脂筏与膜胆固醇外逸对于启动受精的信号传导具有重要作用。Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid compositionfound on the plasma membrane of most mammalian cells. Caveolae is a type of lipid rafts. Caveolins and flotillinsare the marker proteins of caveolae. Lipid rafts or caveolae carry out their specialized role in signal transduction,cellular protein movement and cholesterol homeostasis. That mammalian sperm possess such membrane raftshas been recently demonstrated . The experimental data suggest a role for membrane rafts and membranecholesterol efflux in initiating transmembrane signaling events that confer fertilization competence.

关 键 词：脂筏 精子 信号传导 

分 类 号：Q25[生物学—细胞生物学] Q73