新一代PEG在修饰抗原和药物缓释中的应用  

Application of new generation of polyethylene glycol in antigen modification and drug delivery

作　　者：卞丽红[1] 梅兴国[2] 章扬培[1] 

机构地区：[1]军事医学科学院野战输血研究所,北京100850 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《生命科学》2004年第5期296-300,295,共6页Chinese Bulletin of Life Sciences

基　　金：国家"973"项目(2002CB713804)

摘　　要：聚乙二醇及其衍生物是具有许多优良性质的高分子化合物,由于良好的生物相容性、无毒、无免疫原性,广泛用于生物医学领域。本文总结聚乙二醇的发展历史和新一代聚乙二醇的特点,阐述聚乙二醇化修饰的目的,特别是在抗原修饰、血型改造和细胞移植等方面的应用,重点对聚乙二醇在药物缓释方面的应用进行了系统的综述。Polyethylene glycol (PEG) and its derivatives are a group of compounds with high molecular weightas well as excellent properties such as biocompatibility, non-toxicity and non-immunogenicity. It was widelyused in the field of biomedical science. This review expounded history of PEG development, characters of newgeneration of PEG and purpose of PEG modification, especially in the application of blood conversion and celltransplantation. The use of agent-carrying system based on PEG modification in the drug sustained-releasewas also discussed.

关 键 词：聚乙二醇 抗原 药物 缓释 

分 类 号：R97[医药卫生—药品] R914.2[医药卫生—药学]