氟伐他汀对高脂血症患者血小板活化功能及纤维蛋白原的影响  

The Effects of Fluvastatin on Platelet Activity and Fibrinogen in Patients with Hypercholesterolemia

作　　者：宋志芳[1] 王梦洪[1] 郑泽琪[1] 吴印生[1] 

机构地区：[1]江西医学院第一附属医院心内科,江西南昌330006

出　　处：《实用临床医学（江西）》2004年第5期4-6,共3页Practical Clinical Medicine

摘　　要：目的 :观察氟伐他汀对高脂血症患者血小板CD6 2p、CD6 3及纤维蛋白原的影响。方法 :测定 5 0例高胆固醇血症和混合性高脂血症患者 (治疗组 )降脂治疗前和治疗 (氟伐他汀 4 0mg/d) 8周后及 5 0例健康者 (对照组 )的血脂、血小板CD6 2 p、CD6 3及纤维蛋白原 (Fg)。结果 :治疗组患者CD6 2 p、CD6 3、Fg较对照组明显增高 (P <0 .0 1) ,氟伐他汀治疗 8周后CD6 2p、CD6 3及Fg较治疗前明显下降 (P <0 .0 1)。结论 :氟伐他汀治疗高脂血症患者 ,在有效调脂的同时 。objective: To study the effects of floatation on platelet alpha-granule membrane protein(CD62p)、lysosomal GP53 (CD63)and fibrinogen in patients with hypercholesterolemia.Methods:Fasting serum lipids(TG、TC、HDL-C、LDL-C)、CD62p、CD63 and Fg were measured in 50 healthy subjects and 50 patients with hypercholesterolemia before and after 8 weeks of fluvastatin treatment (40 mg/d).Results:①After fluvastatin treatment,Serum TG、TC、LDL-C were lower and HDL-C were higher than before(P<0.05,P<0.01).②CD62p、CD63 and Fg in the patients with hypercholesterolemia were obviously higher than those in normal subjects(P<0.01).After 8 weeks of fluvastatin treatment,CD62p、CD63 and Fg decreased(P<0.01).Conclusion:Lipid lowering therapy with fluvastatin has beneficial effects on inhibiting the platelet activity and decreasing Fg.

关 键 词：高脂血症 氟伐他汀 血小板活化 纤维蛋白原 

分 类 号：R541.9[医药卫生—心血管疾病] R972.6[医药卫生—内科学]