硝普钠对慢性染铅鼠脑组织中NO、SOD、MDA含量水平的影响  

An Experimental Study on the effect of SNPon the Chang of NO、SOD、MDA in lead-treated mouse brain

作　　者：李淑华[1] 冯芹喜[1] 梁亿红[1] 杨勇[1] 袁宏伟 费春楠 王丽丹[4] 

机构地区：[1]牡丹江医学院,157011 [2]牡丹江市妇产医院检验科 [3]牡丹江市疾病控制中心 [4]牡丹江市第一人民医院

出　　处：《牡丹江医学院学报》2004年第5期6-8,共3页Journal of Mudanjiang Medical University

基　　金：黑龙江省教育厅资助课题 (编号 :95 5 113 7)

摘　　要：目的 :观察硝普钠对慢性染铅鼠脑组织中NO、SOD、MDA含量水平的影响 .方法 :建立慢性染铅鼠模型 ,隔日灌服醋酸铅 ,约 4周 ,观察给药 (硝普钠 )后 3h、12h、2 4h脑组织中NO、SOD、MDA的变化。结果 :实验组NO含量升高 ,SOD活性增强 ,MDA的含量下降 ,各观察时点均与模型组存在显著性差异 (p <0 .0 1)。结论 :给予外源性硝普钠后 ,脑组织脂质过氧化反应减低 ,提示硝普钠对慢性铅中毒鼠脑组织损伤具有保护作用。Objective:This study is to observe the effect of SNP (a sort of No donor drugs) on the Chang of nitrc oxide(NO), Super oxide dismutase(SOD) and malondialdehyde(MDA) in lead-treated mouse brain. Methods : creating the lead exposure model of mouse by feeding PbAc for four weeks ,we dynamically observed the levels of NO、SOD、MDA in lead-treated mouse brain at points after injecting Sodium nitroprusside(SNP).Results:after injecting Sodium nitroprusside (SNP). SOD activity increased and MDA content decreased, and there are significant differences in the level of NO、SOD、MDA between SNP group and lead-treaded model group(P<0.01).Conclusion:the SNP can protect the damage of brain in lead-treated mouse.

关 键 词：硝普钠 脑组织 染铅 慢性 SOD 观察 MDA含量 水平 结论 显著性差异 

分 类 号：R135.11[医药卫生—劳动卫生] R743[医药卫生—公共卫生与预防医学]