间隙连接研究进展  

Research progress of gap junction

作　　者：冯全义[1] 吴泽志[1] 蔡绍晳[1] 李苹[1] 陈秀丽[1] 张秀真[1] 

机构地区：[1]重庆大学生物工程学院教育部生物力学与组织工程重点实验室,400044

出　　处：《国外医学（生物医学工程分册）》2004年第5期297-301,共5页Foreign Medical Sciences(Biomedical Engineering Fascicle)

摘　　要：间隙连接通道是细胞间直接进行物质交流的惟一的膜通道结构。它在细胞间信号传递,物质交流等方面都起着重要的作用。构成间隙连接通道的蛋白亚基为间隙连接蛋白(connexin)。本文就目前已检测到的间隙连接蛋白的种类,间隙连接蛋白的基因突变与疾病的关系,检测间隙连接通讯的常用方法,间隙连接通道的调控机制及间隙连接对肿瘤细胞的影响作一综述。The gap junction channel is the only structure of membrane channel that can communicate material directly between cells. It plays an important role in signal delivery, material communication, and so on. The protein subunit that compose the gap junction channel is connexin. In this article, the author discusses the type of connexin which have been detected at present, the relationship between the gene mutation and the disease of connexin, the method that detect the communication of gap junction, the accomodation mechanism of gap junction channel and the effection of gap junction on tumor cells.

关 键 词：间隙连接 间隙连接蛋白 肿瘤 

分 类 号：Q42[生物学—神经生物学]