新型聚氨酯微球制备及其药物释放规律的研究  

Study on Preparation of Novel Polyurethane Microspheres and Its Drug-Release Behavior

作　　者：唐昌伟[1] 张志斌[1] 邱凯[1] 陈元维[1] 万昌秀[1] 

机构地区：[1]四川大学高分子科学与工程学院,成都610065

出　　处：《聚氨酯工业》2004年第5期15-18,共4页Polyurethane Industry

基　　金：四川省应用基础研究项目 (0 3JY0 2 9- 0 5 9)

摘　　要：以低相对分子质量生物可降解DL 聚乳酸二醇和六亚甲基二异氰酸酯为原料 ,通过悬浮聚合法合成了一种新型聚氨酯微球 (PUMS) ,考察了扩链剂 1,4 丁二醇 (BDO)的含量对微球表面形态和药物包封率的影响。用傅立叶变换红外光谱 (FTIR)、扫描电子显微镜 (SEM )以及激光粒度分析仪对微球的化学结构、表面形态、粒径及其分布进行了表征 ,并以溴百里酚兰为亲水性模型药物 ,初步研究了微球的药物释放行为。结果表明 ,合成的微球的平均粒径 4 7μm ,粒径分布在 10～90 μm之间 ;微球表面有孔 ,但随着BDO含量的增加 ,微球表面变得相对粗糙 ,孔数减少 ,孔径减小 ,直至孔消失 ;BDO含量的增加也使模型药物的包封率减小 ,释放速率变慢 ;药物释放初期出现程度不同的“暴释”现象 。Novel polyurethane microspheres were prepared using suspension polymerization method with hexamethylene diisocyanate as the isocyanate, hydroxyl terminated DL-poly(lactic acid) with low molecular weight as the diol, and 1,4-butanediol(BDO) as the chain-extending agent. Effect of the amount of BDO on the morphology of microspheres was studied with scanning electron microscopy(SEM). Chemical structure of microspheres was studied with fourier transform infrared spectroscopy(FTIR). Particle-size and its distribution of microspheres were determined by a SALD200 laser particle-size instrument. Results showed that the mean particle-size of microspheres was about 47 μm and particle-size was from 10 to 90 μm.The microspheres were porous. However, with increase of the amount of BDO, the number of pores and the pore-size decreased, and the surface of microspheres became rougher. The drug-release behavior of microspheres was investigated with bromothymol blue as a hydrophilic model drug. With increase of the amount of BDO, the amount of entrapped drug decreased,drug-release became slower,and the initial burst was different, but after initial burst the release rate was close to zero order.

关 键 词：生物相容性 生物降解性 药物载体材料 六亚甲基二异氰酸酯 聚乳酸聚氨酯 聚氨酯微球 制备 悬浮聚合法 分散聚合法 聚乳酸二醇 1 4-丁二醇 溴百里酚兰 

分 类 号：TQ460[化学工程—制药化工]