体外膜氧合器对急性肺损伤犬血浆炎症因子的影响  

Effects of ECMO on plasma cytokines in dogs with acute lung injury

作　　者：蒋进军[1] 白春学[1] 王玲[1] 李春[1] 

机构地区：[1]复旦大学中山医院呼吸科,上海200032

出　　处：《中华急诊医学杂志》2004年第5期299-301,共3页Chinese Journal of Emergency Medicine

基　　金：上海市科技发展基金资助项目 ( 0 3DZ19619)

摘　　要：目的　研究体外膜氧合器 (extracorporealmembraneoxygenation ,ECMO)对急性肺损伤犬血浆炎症因子的影响。方法　 10只健康杂种犬 ,随机分成机械通气 (MV)和体外膜氧合器联合机械通气 (ECMO+MV)两组。采用静脉注射油酸复制犬急性肺损伤模型 ,然后进行MV或ECMO治疗 2 4 0min。应用ELISA法测定血浆中细胞因子 (IL - 6、IL - 8、IL - 10和IL - 12 )。结果　应用ECMO可以改善低氧血症 (P <0 0 5 ) ,但是对于肺动脉压力没有明显改善。使用ECMO后血浆中IL - 6、IL - 8和IL - 19浓度较对照组升高(P <0 0 5 ) ,IL - 10浓度则没有明显变化。结论　体外膜氧合器可以改善急性肺损伤犬的氧供 ,但是对于肺动脉压力的高没有降低作用 ,而且使用体外膜氧合器后血浆中多种细胞因子显著升高。Objective To study effects of ECMO on plasma cytokines in dogs with acute lung injury.Methods Ten pentobarbital￣anesthetized dogs were randomly divided into a control (mechanical ventilation,MV)group(n=5) and MV+ECMO group(n=5).Acute lung injury model induced by canine oleic acid was set up through intravenously injection of oleic acid,and then performed MV or MV+ECMO for 240 min.Plasma cytokines(IL-6,IL-8,IL-10 and IL-12)were detected by ELISA.Results ECMO increased the oxygenation (P<0.05),but there were no changes in the pressure of the pulmonary artery.There was noticeable increase in plasma IL-6,IL-8 and IL-12 level(P<0.05),except IL-10.Conclusion ECMO increases the oxygention of dogs with acute lung injury,and cannot improve the pressure of the pulmonary artery.ECMO incerases the cytokines level in plasma.

关 键 词：体外膜氧合器 急性肺损伤 犬 血浆炎症因子 机械通气 

分 类 号：R563.8[医药卫生—呼吸系统]