急性高血压对成年及老年大鼠血脑屏障通透性的影响  

Influence of acute hypertension on blood brain barrier permeability in rats

作　　者：苏小军 宋运琴[2] 陈知进[2] 张宏[2] 

机构地区：[1]解放军第三○四医院麻醉科,北京市100037 [2]解放军总医院麻醉科

出　　处：《临床麻醉学杂志》2004年第8期474-476,共3页Journal of Clinical Anesthesiology

摘　　要：目的　探讨急性高血压对成年及老年大鼠血脑屏障通透性的影响。方法　用依文氏蓝染色、光镜及镧醛灌注电镜法观察去氧肾上腺素诱发的急性高血压对成年及老年大鼠血脑屏障通透性的影响。结果　成年及老年组大鼠皮质及小脑蓝染程度明显高于尾壳核、海马和丘脑。光镜下可见局灶性神经细胞肿胀、尼氏小体溶解 ,胞浆空亮 ,细胞嗜酸性增强。电镜观察内皮细胞及基底膜完整 ,镧离子全部位于血管腔内。结论　去氧肾上腺素诱发的高血压可以引起广泛的血脑屏障通透性升高 ,以皮质和小脑更为明显。同时可引起中枢神经细胞局灶性肿胀变性。Objective To evaluate the effect of acute hypertension on the permeability of blood brain barrier in aged and adult rats. Methods The effect of induced hypertension on the permeability of blood brain barrier was examined by Evans blue staining, optical microscop and electromicroscop. Results Evans blue staining of the cortex and cerebellum was higher than that of the caudatoputamen,hippocampus and thalamencephalon. The swelling of neuron, lysis of Nissl bodies, increased eosinophilia of neuronal cytoplasm, or vaculated cytoplasm were noted focally under optial microscop. Lanthanum in the blood vessel was not seen under electromicroscope. Conclusion Acute hypertension induced by phenylephrine may enhance the permeability of blood brain barrier with the neuron degeneration and swelling, predominately in the cerebellum and cerebral cortex.

关 键 词：急性高血压 成年 老年 大鼠 血脑屏障通透性 

分 类 号：R544.1[医药卫生—心血管疾病]