D-(-)-O,O-二硬脂酰基泛酸苄酯的合成与应用研究  

THE SYNTHESIS AND APPLICATION OF D-(-)-O,O-BENZYLDISTEARYLPANTOTHENATE

作　　者：毛璞[1] 肖咏梅[1] 王宏雁[1] 赵俊廷[1] 江秀明[1] 卢奎[1] 

机构地区：[1]郑州工程学院化学化工系,河南郑州450052

出　　处：《郑州工程学院学报》2004年第3期27-29,共3页

基　　金："九五"国家重点科技项目(攻关)计划项目的子专题(96-009-02-005)

摘　　要：以D＿(+)＿泛酸钙(维生素B3)为原料通过化学修饰研制出一种水难溶型维生素B3衍生物(D＿(-)＿O,O＿二硬脂酰基泛酸苄酯),产品小试收率为79%,含量高于97%.产品的熔点为22～28℃,常温下5h水中流失率小于1%.饲喂结果表明:饲料中添加水难溶型维生素B3可以提高牙鲆幼鱼的增重率.A new compound D_(-)_O,O_benzyldistearylpantothenate was synthesized by the reaction of calcium pantothenate with benzyl chloride and stearyl chloride. The structure of the product was identified by elemental analysis, IR and^1HNMR. Stearyl chloride (0.9 mol) was added relaxedly to the solution of D_benzylstearate (123 g, 0.4 mol) in pyridine (250 mL). The mixture was stirred for 2 h under design temperature. After evaporation of the solvent and removal of the others, D_(-)_O,O_benzyl bistearylpantothenate(358 g) was obtained. The melting point was 22～28 ℃. [α]_D^(20)=-0.2°(DMF). Elemental analysis: C, 73.91; H, 11.32; N, 1.44. Anal. Calcd.according to C_(59)H_(91)O_7N·0.25C_(18)H_(36)O_2: C, 74.30; H, 11.03; N, 1.53. IR: 3　330 cm^(-1) (w), 1　785 cm^(-1) (s), 1　730 cm^(-1) (vs), 1　670 cm^(-1) (m), 1　530 cm^(-1) (w), 1　490 cm^(-1) (w), 1　450 cm^(-1) (m), 1　220 cm^(-1) (vs), 720 cm^(-1) (s).~1HNMR:δ7.46～7.11(m, 5H, ArH), 5.20～3.60(m, 7H, OCH, N—CH_2—), 2.50～2.20(m, 6.5H, CH_2—CO),1.50～1.10(br, 68H, —CH_2—), 1.00～0.80(m, 13H, CH_3). The yield of hydrophobic vitamine B_3 was 79% in laboratory and was 80% in magnified experiment. The purity was over 97%. The loss rate of hydrophobic vitamine B_3 was less than 1% in water within 24 h at room temperature. The feeding results showed that the product could increase the weight of leftege flounder parr.

关 键 词：D-(-)-D O-二硬脂酰基泛酸苄酯 合成 化学修饰 水难溶型维生素B3 饲料添加剂 

分 类 号：S816.7[农业科学—饲料科学]