两种药物联合应用治疗不稳定型心绞痛的临床效果  

CLINICAL STUDY OF TREATMENT UNSTABLE ANGINA WITH LOW-MOLECULAR-WEIGHT HEPARIN CALCIUM AND COMPOUND SALVIA MILTIORRHIZE INJECTION.

作　　者：李忠山[1] 郭西文[1] 杨永平[1] 季秀丽[2] 晁金梅 

机构地区：[1]山东省菏泽医学专科学校,菏泽274030 [2]山东省菏泽市立医院 [3]山东省菏泽市第二人民医院

出　　处：《现代预防医学》2004年第3期422-423,共2页Modern Preventive Medicine

摘　　要：目的 :探讨低分子肝素钙与复方丹参联用治疗不稳定型心绞痛的临床效果。方法 :96例不稳定型心绞痛患者被随机分成治疗组与对照组 (各 4 8例 ) ,在常规治疗基础上治疗组给予低分子肝素钙 5 0 0 0 IU腹部皮下注射 ,1次 /日 ,连用7日 ,复方丹参注射液 16 ml入液静脉点滴 ,1次 /日 ,连用 15日 ;对照组给予阿司匹林 5 0 m g每晚一次口服 ,连用 30日 ;然后进行疗效观察 ,所获数据进行 χ2或 t检验。结果 :治疗后治疗组总有效率 (93.75 % )及心电图改善情况均优于对照组(P<0 .0 0 5 ) ,而心绞痛发作频率治疗组为 (3.1± 0 .6 )次 /周 ,对照组为 (4.9± 0 .8)次 /周 ,差异有统计学意义 (P<0 .0 0 1)。结论 :低分子肝素与复方丹参联用治疗不稳定型心绞痛安全。Objective:To observe the therapeutic effects and safety of low-molecular-weight heparin calcium and compound salvia miltiorrhize injection for treat unstable angina.Methods:All patients were divided into two groups randomly: therapeutic group and control group.The patients in theapeutic group were treated by hypodermic injection of low-molecular-weight heparin calcium and intravenous injection of compound salvia miltiorrhize. The control group patients were given aspirin for oral use.Results: The effective rate and the reform of electrocardiogram in therapeutic group were superior to control group significantly (P<0.005), but the angina attack frequency in therapeutic group was lower than the later(P<0.001).Conclusion:The combined use low-molecular-weight heparin calcium and compound salvia miltiorrhize injection for the treatment of unstable angina is a safe and effective way.

关 键 词：药物治疗 不稳定型心绞痛 联合用药 低分子肝素钙 复方丹参 

分 类 号：R541.4[医药卫生—心血管疾病]