高血压患者血浆ET、TXB_2和6-酮-PGF_(1a)测定的临床意义  

Clinical significance of determination of plasma endothelin,thromboxane and prostacylin in patients with hypertension

作　　者：纪树岚[1] 徐惠民[1] 王玉平[1] 秦继宝[1] 

机构地区：[1]江苏省连云港市东方医院内科,222000

出　　处：《淮海医药》2004年第6期443-444,共2页Journal of Huaihai Medicine

基　　金：江苏省连云港市卫生局科研资助课题 (0 30 2 8)

摘　　要：目的　了解血浆内皮素 (ET)、血栓素 (TXB2 )、前列环素 (PGF1 a)在高血压病中的作用。方法　应用放射免疫分析法测定 5 5例高血压患者、38例正常人血浆中 ET、TXB2 、PGF1 a含量。结果　高血压患者血浆中 ET、TXB2水平非常显著地高于正常人组 (P<0 .0 1 ) ,而 PGF1 a水平则显著地低于正常人组 (P<0 .0 1 ) ,与血压的高低密切有关。结论　高血压患者血管内皮细胞存在内分泌功能紊乱、ET合成释放增加 ,PGF1 a水平降低 ,两者反馈调控失衡 。Objective To study the role of plasma ET,TXB 2 and PGF 1a in the case of hypertension.Methods The concentration of plasma ET,TXB 2 and PGF 1a levels were detected by radioimmunoassay in 55 patients with hypertension and 38 normal controls.Results The plasma ET and TXB 2 levels in patients with hypertension were significantly higher than those in normal controls( P <0.01),while plasma PGF 1a levels remarkably lower( P <0.01).The score index of hypertension was significantly correlated to the levels of plasma ET,TXB 2 and PGF 1a levels.Conclusion Endocrine functional disorder of vessels results in increase of ET and decrease of PGF 1a .The normal feed-back modulation mechanism might be disturbed.It plays an important role in the pathogensis of hypertension.

关 键 词：TXB2 高血压患者 血浆ET 正常人 临床意义 内分泌功能紊乱 人血浆 反馈调控 

分 类 号：R544.1[医药卫生—心血管疾病] R743[医药卫生—内科学]