实时功能磁共振成像技术对运动皮层的定位探讨  

Motor cortex by real-time imaging process functionalMRI during finger movements

作　　者：谭长连[1] 吴大兴[2] 刘亚东[3] 颜莉蓉[3] 袁术文[1] 卓尚丕[1] 贺忠[1] 杜万萍[1] 司徒卫军[1] 

机构地区：[1]中南大学湘雅二医院放射科,长沙410011 [2]中南大学湘雅二医院心理中心,长沙410006 [3]国防科技大学机电工程与自动化学院,长沙410011

出　　处：《中南大学学报（医学版）》2004年第4期397-400,共4页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金 (30 1 0 0 0 54)

摘　　要：目的 :探讨运动皮层实时脑功能的成像技术和Functool,ICA和SPM的后处理技术。方法 :1 5例正常志愿者进行 2 3次对指运动实时脑功能扫描 ,经Functool,IAC和SPM软件后处理成像 ,并对 3种软件的成像进行分析。结果 :Functool处理后 ,2 3次实时脑功能成像显示了手指运动对侧初级皮层运动区 /感觉区 (M1 /S1 )、辅助运动区 (SMA)明显激活 ,同侧激活区较小或者未见激活区。双侧小脑皮质有明显激活 ,同侧较大。 5次运动前区双侧有激活 ,4次对侧有较小激活区。 1 2次ICA ,SPM所获图像与相应的Functool图像一致。结论 :实时脑功能成像能对全脑进行实时扫描 ,Functool。Objective To explore the techniques of RTIP fMRI scanning and the correspondence between structure and functional changes of motor cortex during self paced finger movements by RTIP fMRI in normal volunteers. Methods The 15 healthy volunteers were studied by RTIP fMRI, and the activation tasks consisted of self paced finger movements performed with the right and the left hands. Image postprocessing was done on the workstation by “correlation coefficient” algorithm analysis method, IAC and SPM software.Results There was a good correspondence between the anatomical landmarks of the somatotopical organization of primary motor areas in the 15 volunteers; during the finger tasks, the functional changes occurred in the contralateral primary motor somatosensory cortex (M1/S1) , the supplementary motor area (SMA), and the ipsilateral primary motor cortex.Conclusion RTIP, a promising new technique , can localize the motor cortex accurately. It is superior to any other fMRI techniques, and may be used widely in the function research of the brain.

关 键 词：运动皮层 激活 双侧 磁共振成像技术 同侧 脑功能成像 ICA 辅助运动区 

分 类 号：R445.2[医药卫生—影像医学与核医学]