母血、羊水中IGF水平与胎儿宫内生长受限关系的研究  

The Relationship between Insulin-like Growth Factors and Intrauterine Growth Retardation in Maternity Blood and Amniotic Fluid

作　　者：王晓春[1] 肖平[2] 刘惠宁[3] 黄顺玲[3] 陈卫群[1] 吴佳捷[3] 

机构地区：[1]中南大学医学技术与情报学院医学检验系,湖南长沙410013 [2]中南大学湘雅二医院 [3]中南大学湘雅医院

出　　处：《实用预防医学》2004年第5期892-893,共2页Practical Preventive Medicine

基　　金：湖南省科技厅科技资助项目 (编号 0 3SSY30 94)

摘　　要：目的　探讨胰岛素样生长因子 -Ⅰ (IGF -Ⅰ )和IGF -Ⅱ与胎儿生长发育的关系。　方法　抽取 15例分娩IUGR胎儿 (IUGR组 )及 2 0例分娩正常儿 (对照组 )产妇肘静脉血、新生儿脐静血及羊水。采用放射免疫法及免疫放射法分别测定其IGF -Ⅰ、IGF -Ⅱ水平。　结果　IUGR组产妇血清IGF -Ⅰ水平低于对照组 ,IGF -Ⅱ水平无显著差异 ;IUGR组脐血及羊水中IGF -Ⅰ、IGF -Ⅱ水平较对照组显著降低。　结论　检测母血及羊水中IGF -Ⅰ、IGF -Ⅱ水平可监测胎儿生长发育 ,早期诊断IUGR。Objective To explore the effect of insulin-like growth factor-Ⅰ(IGF-Ⅰ) and insulin-like growth factor-Ⅱ(IGF-Ⅱ) on the fetal growth. Methods Samples of maternal blood and matched umbilical cord blood and amniotic fluid were collected at the time of delivery from 20 normal pregnancies (control group), and 15 pregnancies with intrauterine growth retardation(IUGR group).Serum and amniotic fluid IGF-Ⅰ and IGF-Ⅱ were measured by radioimmunoassay(RIA) and immunoradiometric analysis(IRMA). Results The maternal IGF-Ⅰlevels in IUGR group were significantly lower than those in control group. The fetal and amniotic fluid IGF-Ⅰand IGF-Ⅱ level in IUGR group were lower than those in control group. Conclusions The assay of maternal and amniotic fluid IGF-Ⅰ,IGF-Ⅱ can predict the condition of fetal growth and development.

关 键 词：妇产科学 羊水 母血 胰岛素样生长因子 胎儿宫内生长受限 

分 类 号：R71[医药卫生—妇产科学]