158例流行前无偿献血者血清SARS相关冠状病毒抗体检测  

Detection of SARS-associated coronavirus in 158 volunteer blood-donors before SARS epidemic

作　　者：彭道波[1] 赖福才[1] 赵晖[1] 王燕军[1] 陈家芳[1] 陈金军[1] 侯金林[1] 

机构地区：[1]南方医院

出　　处：《解放军医学杂志》2004年第9期757-758,共2页Medical Journal of Chinese People's Liberation Army

基　　金：SARS军队指令性课题 (编号 0 3F0 0 5)

摘　　要：目的　探讨输入不稳定的血液及其制品而传播严重急性呼吸综合征 (SARS)相关冠状病毒的可能性。方法　采用ELISA法对 1 5 8例医务工作者流行前无偿献血的血清进行SARS相关冠状病毒抗体检测 ,对结果阳性者及其长期接触者进行随访。结果　在所有血清样本中 ,SARS抗体阳性 2例 (1 .2 7% ) ;阳性者本人、长期接触者以及受血者均无感染SARS的病史。结论　SARS病毒既往并未在医院内流行 ,其感染途径不明。输入不稳定的血液制品有感染SARS的危险只是理论上的推断 ,随着对SARS研究的深入 ,其传播途径将更加明确。Objective To investigate the possibility of transmission of severe acute respiratory syndrome (SARS) related coronavirus by transfusion of unreliable blood and relevant product. Methods ELISA technique was used to detect the antibodies of SARS associated coronavirus in the plasma from 158 volunteer blood donors, who were medical workers, before the SARS epidemic. The subjects with positive result were place under surveillance. Results There were two positive samples in 158 tested samples. The subjects with positive test result did not have the history of SARS infection. Conclusion There was no epidemic of SARS in the hospital. The transmission pathway of SARS was unknown. It seems that the risk of transmitting SARS by unreliable blood product transfusion is just a theoretical hypothesis. With further investigation of SARS, its transmission pathway will be hopefully made known.

关 键 词：严重急性呼吸综合征 流行前 无偿献血 抗体 

分 类 号：R563.19[医药卫生—呼吸系统]