单纯收缩期高血压患者高胆固醇血症与肱动脉内皮功能的关系  

Relationship between Endothelial Function of Patients with Hypertension and Hypercholesterolemia

作　　者：陈丽[1] 高兴玉[1] 曹礼庭[1] 张敏慧[1] 张小明[1] 

机构地区：[1]川北医学院附属医院心内科,637000

出　　处：《中国医学计算机成像杂志》2004年第4期278-280,共3页Chinese Computed Medical Imaging

摘　　要：目的 :研究高血压患者内皮功能与高胆固醇血症的关系。材料和方法 :80例诊断明确的高血压伴高胆固醇血症患者 ,利用高频超声进行无创性的血管内皮功能检测 ,同时测定血液中胆固醇的浓度 ,比较这些患者内皮功能与高胆固醇血症的关系。结果 :加压充血后 ,肱动脉管径平均扩增率 (Flow -MD)与胆固醇浓度呈负相关 ,相关系数是 -0.339,P<0.01。结论:高血压患者血液中胆固醇浓度增高与动脉内皮细胞功能受损、粥样硬化关系密切。Purpose:To study relationship between endothelial function and hypercholesterolemia in patients with hypertension.Materials and Methods:80patients with hypertension were selected.B-mode ultrasound was applied to scan brachial arteries of all patients.Checked and measured diameter of brachial arteries during at rest and reactive hyperemia caused by endothelium-dependent dilatation.The concentration of cholesterolemia in blood were determined.Then analysed relationship between endothelial function and hypercholesterolemia in the patients.Results:There is negative correlativity between flow-mediated diˉlatation(Flow-MD%)and cholesterolemia.The correlation coefficient was-0.339,P<0.01.Conclusion:There is significant relation between increased concentration of cholesterolemia in blood and damaged endothelial function in patients with hypertension.

关 键 词：高胆固醇血症 高血压患者 肱动脉内皮功能 单纯收缩期高血压 诊断 血液 动脉内皮细胞 MD 相关系数 

分 类 号：R544.1[医药卫生—心血管疾病] R589.2[医药卫生—内科学]