半夏泻心汤不同性味拆方对胃溃疡大鼠血清胃泌素的影响  

Effects of Separate Parts of “Banxia Xiexin Decoction” on Serum Gastrin in Rats of Gastric Ulcer

作　　者：赵琰[1] 李宇航[1] 王庆国[1] 屈会化[1] 周冠芬[1] 贾玉森[1] 张冬梅[1] 钟相根[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《上海中医药杂志》2004年第10期45-47,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目 (39870 95 0 );国家中医药管理局重点资助项目 (972 0 6 6 )

摘　　要：为研究半夏泻心汤的配伍规律 ,按不同性味将该方拆成辛甘药 (半夏、干姜 ,X)组 ,苦味药 (黄芩、黄连 ,K)组 ,甘味药 (人参、炙甘草、大枣 ,G)组 ,并进行交叉组合成XK、XG、KG组 ,及全方 (Q)组。Wistar大鼠按改良Okabe法制作慢性胃溃疡模型并分组后 ,分别给予相当于成人用量 10倍的上述各组药物 ,连续用药 3周后 ,比较各组大鼠血清胃泌素的水平。结果 :X、K、G、KG组药物对胃泌素无明显影响 ;XK、XG组药物对胃泌素有明显影响 ,其中XG组的作用与Q组相近。提示 :不同辛味药物之间的配伍 。To study the combining laws of “Banxia Xiexin Decoction”, the Decoction was separated into several parts: X group with acrid herbs, K group with bitter herbs and G group with sweet herbs; and the three groups were then combined by twos: XK group, XG group and KG group; the whole decoction (Q group) was also observed. Wistar rats were modeled by Okabe method to be of chronic gastric ulcer and given corresponding herbs, the serum gastrin in all the groups were detected after 3-week treatment. Results: There were no differences in gastrin among X, K, G and KG groups; gastrin changed in XK and XG groups; XG group Q group worked similarly. It is revealed that herbs with different acridity work differently.

关 键 词：半夏泻心汤 药物辛味 拆方 胃溃疡 大鼠模型 血清胃泌素 

分 类 号：R285.5[医药卫生—中药学]