新生儿缺氧缺血性脑病用地塞米松大剂量短程疗法的临床观察  

Clinical observation of the heavy dose , short course treatment with dexamethasone on neonates with hypoxic ischemic encephalopathy

作　　者：傅丕梁 刘咏[1] 

机构地区：[1]安徽省安庆市第一人民医院儿科,安徽安庆246003

出　　处：《河北医学》2004年第11期978-980,共3页Hebei Medicine

摘　　要：目的 :观察大剂量地塞米松 (Dxm)早期短程疗法治疗新生儿缺氧缺血性脑病 (HIE)的效果和对肾上腺皮质功能的影响。方法 :选择临床轻中度HIE 3 0例 ,按入院先后顺序随机分为两组 ,观察组在常规治疗的基础上加用地塞米松 2 .5～ 3mg/kg·d分 2～ 3次连续静脉滴注 3d ,对照组仅给常规治疗。结果 :两组疗效比较差异显著 (P <0 .0 5 ) ,观察组治疗后促肾上腺皮质激素 (ACTH)不降反升且差异非常显著 (P <0 .0 1 )。结论 :本研究显示该疗法是安全有效的 ,并未出现血皮质醇 (PTC)Objective: The purposes of the study were to observe the effects of heavy dose , short course treatment with dexamethasone(Dxm) on the neonates with hypoxic ischemic encephalopathy(HIE) ,and the affection on the adrenocortical function . Method: Selecting 30 HIE infants who were low-grade or middle-grade ,then according to the sequence of the infants were being in hospital ,classified them into two groups randomly : control and observation groups.In the observation ,on the basis of normal treatment ,the infants were subjected to Dxm at a dose of 2.5～3 mg/kg per day ,twice daily or three daily ,and it was lasting three days .while the control group only received normal treatment .Result: The therapy effects were significant differences between two groups (p<0.05). In the observation, the adrenotrophin (ACTH) level increased instead of decrease and the differences were significant (p<0.01). Conclusion: The exploration showed that this therapy was safe and effective , never led to the disorderly of plasma cortisol (PTC) level and the irreversible inhibition of the adrenocortical function.

关 键 词：新生儿缺氧缺血性脑病 地塞米松 促肾上腺皮质激素 血皮质醇 

分 类 号：R722.1[医药卫生—儿科]