芍丹乙肝口服液澄清工艺的研究  

Study on clarification process of Shaodan yigan oral liquid

作　　者：赵军[1] 沈季元[1] 李献林[1] 邢建国 

机构地区：[1]新疆医科大学第一附属医院药剂科,新疆乌鲁木齐830054 [2]新疆药物研究所,新疆乌鲁木齐830000

出　　处：《中国现代应用药学》2004年第5期411-413,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的　优选芍丹乙肝口服液的澄清工艺。方法　通过对水浸出物收率、总多糖含量及芍药苷含量的测定 ,比较了乙醇沉淀法、高速离心法、吸附澄清技术 3种澄清工艺的差异。结果　 3种澄清工艺对 3个指标均有不同程度的影响 ,其中吸附澄清技术能使水浸出物收率降至 18%左右 ,有效成分保留率在 80 %以上 ,且溶液澄清。OBJECTIVE To choose the best clarification process of Shaodan yigan oral liquid.METHOD By determining dry extract percent,total polysaccharide content and paeonoside content,three clarification process including ethanal precipitation,high-speed centrifugation and adsorption clarification technic were compared.RESULTS Three clarification process had different level effect on the three index.Adsorption clarification technic could reduce the dry extract percent to 18% or so,make the retention rate of the active components above 80%.CONCLUSION Adsorption clarification technic can be used as clarification process of Shaodan yigan oral liquid.

关 键 词：乙肝 口服液 澄清工艺 澄清技术 水浸出物 高速离心法 芍药苷含量 收率 吸附 

分 类 号：R283[医药卫生—中药学] R512.62[医药卫生—中医学]