海生素注射液抗肿瘤作用的实验研究  

An experiment study on antitumor effect of Haishengsu injection

作　　者：柳忠旭 战松梅[2] 姚如永[3] 房丽华[3] 杨秀 王春波[2] 

机构地区：[1]青岛市崂山区卫生局 [2]青岛大学 [3]青岛大学医学院附属医院 [4]青岛海生肿瘤医院,青岛266003

出　　处：《中国海洋药物》2004年第5期35-37,共3页Chinese Journal of Marine Drugs

摘　　要：目的 :研究海生素的抗肿瘤效果。方法 :采用小鼠移植性实体瘤S180 、艾氏腹水瘤 (EAC)和肝癌实体瘤 (Heps)模型的抑瘤试验 ,尾静脉给予小鼠不同剂量的海生素 ,计算抑瘤率和荷瘤小鼠生命延长率。结果 :海生素在 4 90～ 10 0 0mg·kg- 1·d- 1剂量范围内对小鼠S180 和Heps的抑瘤率分别达到 4 1.10 %～ 4 9.0 8%和 36 .2 9%～ 4 9.19% ,对EAC小鼠的生命延长率为 2 2 .93%～ 6 9.98%。结论 :海生素对荷瘤小鼠具有明显的抑瘤作用 ,在有效治疗肿瘤的同时对小鼠体重无明显影响。Objective To investigate the antitumor effect of Haishengsu injection extracted from marine shellfish. Methods Transplant tumor models of sarcoma 180 (S 180), Ehrlich ascites carcinoma (EAC), and hepatoma (Heps) in mice were established. Different doses of Haishengsu injection were given to the mice and the tumor inhibition rates of Haishengsu injection, life span of the mice were calculated. Results The tumor inhibition rates of haishengsu injection (490～1000mg·kg -1·d -1,iv) were 41.10%～49.08% in mice with S 180 and 36.29%～49.19% in mice with hepatoma,respectively. The same doses of Haishengsu injection prolonged the life spans of EAC-bearing mice by 22.93%～69.98%. Conclusion The haishengsu injection has the antitumor effects on the tumor-bearing mice without evident side effects.

关 键 词：荷瘤小鼠 抑瘤率 生命延长率 抗肿瘤作用 注射液 S180 实体瘤 海生素 体重 剂量 

分 类 号：R285.5[医药卫生—中药学] S828[医药卫生—中医学]