海洋来源的放线菌次级代谢产物及其生物活性  

Secondary metabolites of marine-derived actinomycete microbes and their bioactivities

作　　者：张清丽[1] 顾谦群[1] 崔承彬[1] 方玉春[1] 刘红兵[1] 朱天骄[1] 

机构地区：[1]教育部海洋药物重点实验室

出　　处：《中国海洋药物》2004年第5期49-54,共6页Chinese Journal of Marine Drugs

基　　金：国家973项目(G1998051113);国家自然科学基金项目(39825126及30171102);国家863项目(2001AA624020);山东省自然科学基金重点项目(Z2001C01);山东省科技攻关计划项目(0121100107);青岛市自然科学基金资助(042JZ81)

摘　　要：放线菌是迄今最重要和最大的药用微生物种群。海洋放线菌生存于苛刻特殊的海洋环境 ,使其具备了复杂独特的代谢途径 ,其次级代谢产物在结构类型以及在生物活性等方面都呈现出与陆生放线菌不同的特点和多样性。多年来 ,诸多结构新颖、生物活性显著的天然活性产物持续从海洋来源放线菌代谢产物中被发现 ,这些活性化合物为新药研究提供了丰富的先导化合物 ,有些已进入研发阶段。近年 ,海洋放线菌活性产物的研究仍然是海洋微生物产物研究中值得关注的一个热点。本文按化合物结构类型简要介绍了海洋来源放线菌代谢产物及其生物活性的研究概况。Actinomycete microbes are the most important and largest class of microbes for medicinal usage up to date. Marine-derived actinomycete microbes possess metabolic capabilities different from those of terrestrial actinomycete microbes, which were obtained during their evolution in the marine environment, resulting in the distinct peculiarity and wide diversity of their metabolites in chemical structure and biological activity. Numerous natural products with novel structure and distinct biological activity have been discovered from the secondary metabolites of marine-derived actinomycete microbes. These bioactive compounds provided much valuable leading compounds for new drug development, and some of them even have been being in a stage of product development. Current studies on the bioactive metabolites of marine-derived actinomycete microbes are yet very hot and important in the marine-derived microbial natural products research field. Here, we review briefly the research advances achieved recently in the studies on the secondary metabolites of marine-derived actinomycete microbes and their biological activities in terms of the structural types of the metabolites.

关 键 词：海洋放线菌 代谢产物 化学成分 生物活性 

分 类 号：R931.711[医药卫生—生药学]