新生儿血清瘦素水平变化与IGF-I、生长激素等相关因素的分析  

Investigate changes of serum leptin levels and relationship with growth hormone,IGF-I in neonate

作　　者：潘小梅 宋金枝 陈庭 唐沂 刘小红[2] 

机构地区：[1]暨南大学医学院第二附属医院深圳市人民医院儿科,深圳518020 [2]广东省深圳市儿童医院

出　　处：《中国优生与遗传杂志》2004年第5期92-93,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的　探讨新生儿血清瘦素来源及其与胰岛素样生长因子 -I(IGF -I)和生长激素的关系。方法　采用放射免疫法检测 80例新生儿静脉血和脐血瘦素水平 ,根据不同胎龄新生儿出生体重值分为大于胎龄儿组 2 8例 ,适于胎龄儿组 36例 ,小于胎龄儿组 16例 ;采用Rohrer’s指数 =出生体重 (g)× 10 /身长 (cm) 3 估测新生儿营养状态。结果　早产儿血清瘦素水平明显低于足月儿 (0 .6 6± 1.0 3ng/mlvs 3.5 9± 2 .16ng/ml,P <0 .0 1=;适于胎龄儿血清瘦素水平 (3.0 6± 0 .96ng/ml明显低于大于胎龄儿 (4.0 3± 2 .2 2ng/ml) ,而高于小于胎龄儿 (1.13± 1.98ng/ml) ;足月新生儿血清瘦素水平与Rohrer’s指数、新生儿体重、胎龄、血清IGF -I、生长激素水平呈显著正相关。结论　新生儿体内瘦素主要来源于自身脂肪组织 ,它反映新生儿的生长营养状态 ,推测瘦素可能通过IGF -I、生长激素共同调节新生儿的生长发育 。Objective: To investigate the origin of serum leptin in newborn and its relationship with growth hormone, IGF-I in neonate. Methods:the serum levels of leptin in 80 newborns and 46 cord serum were examinated by radio-immuno-assay(RIA). According to the neonatal weight of vary gestation ages to divide into the large for gestational age(LGA) group 18 cases, the appropriate for gestational age(AGA) group 32 cases and small gestational age (SGA) 16 cases. Linear regression analysis was used to explore the relationship between serum leptin levels and anthropometric measures and Multiple regression analysis then applied to determine the correlative factors associated with leptin. Results: The levels in the preterm newborns were significantly lower than those in term neonates (0.66±1.03ng/ml vs 3.59±2.16ng/ml, t=2.639 P<0.01);The leptin values in AGA newborns were significantly greater than those in the SGA, and significantly lower than those in LGA neonates. Serum leptin correlated with neonatal weight, Rohrer's index, gestational ages and correlated with blood IGF-I and growth hormone after multiple regression analysis. Conclusion: the adiposity tissues is an important resource of leptin in newborn. The serum leptin level can be taken as a valuable index of fat mass in neonate. We hypothesize that leptin might play an neonatal important role during fetal and neonatal growth with IGF-I and growth hormone.

关 键 词：瘦素 血清 新生儿 生长激素 IGF-I 

分 类 号：R722.1[医药卫生—儿科]