IL-23的研究进展  

Advances in the Study of IL-23

作　　者：徐玢[1] 马小彤[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所,天津市300020

出　　处：《医学分子生物学杂志》2004年第5期302-305,共4页Journal of Medical Molecular Biology

摘　　要：IL 2 3是新近发现的一种细胞因子 ,主要来源于活化的单核巨噬细胞和B细胞。它具有多种生物学功能 ,能促进T细胞尤其是CD4 + T细胞增殖 ,促进T细胞、抗原提呈细胞产生IFN γ与IL 12 ,对树突状细胞的共刺激功能起调节作用 ,具有抗肿瘤和抗转移活性 ,而且与自身免疫和炎症反应疾病密切相关。IL-23 is a recently discovered heterodimeric cytokine. It is mainly produced by activated macrophages and B cells. IL-23 has been shown to possess multiple biological activities. For example, it can enhance T cells especially CD4 + T cell proliferation and interferon-gamma, IL-12 production from T cells, myeloid antigen-presenting cells (APCs). It can also modulate the costimulatory function of dendritic cells (DC). Additionally, recent studies demonstrated that IL-23 has antitumor and antimetastatic activity, and it may also be involved in the development of autoimmune diseases and inflammatory diseases.

关 键 词：IL-2 T细胞增殖 共刺激 抗原提呈细胞 IL-12 研究进展 自身免疫 生物学功能 发现 抗肿瘤 

分 类 号：R392[医药卫生—免疫学] R730[医药卫生—基础医学]