绝经妇女血清PRL的测定研究  

Study on the Serum Prolactin (PRL) Level in Post-Menopausal Women

作　　者：李文琦[1] 周争立[2] 李欣[1] 周激文[1] 

机构地区：[1]云南省计划生育技术科学研究所,650021 [2]云南省第一人民医院妇科,650032

出　　处：《放射免疫学杂志》2004年第5期339-341,共3页Journal of Radioimmanology

摘　　要：目的 :探讨测定绝经期妇女血清泌乳激素 (PRL)的价值。方法 :用放射免疫分析测定 5 96例绝经期妇女血清的PRL水平 ,这些妇女的年龄为 (4 5～ 5 9)岁 ,平均 5 5岁。结果 :在所有测定对象中有 77例为高PRL血症 ,占总数 13% ,其中 31例证实有垂体微腺瘤存在 ,她们的更年期综合征及骨质疏松比其他妇女严重 ,而高PRL血症要慎用雌激素。结论 :本文结果说明 ,测定绝经期妇女血清PRL的水平具有非常重要的意义。Objective To explore the clinical value of determination of serum PRL levels in post-menopausal women. Methods Serum PRL levels were determined with RIA in 596 post-menopausal women (age 45～59, mean 55). Results The normal range of serum PRL level in this laboratory was 0～30ng/ml. Among the 596 women tested, 77 (13%) had their PRL levels above 30ng/ml. Further investigation with CT and/or MRI revealed presence of micro-pituitary-adenoma in 31 of the 77 subjects. Symptoms of menopausal syndrome and osteoporosis were much more severe in women with hyperprolactinemia then in those without. Conclusion As hyperprolactinemia might be a high risk factor for development of breast cancer, hormone replacement therapy (HRT) in menopausal women with hyperprolactinemia should be applied very cautiously, even withheld at all. Determination of serum prolactin levels in post-menopausal women is of practical clinical value.

关 键 词：PRL 血清 绝经期妇女 血症 绝经妇女 严重 更年期综合征 水平 雌激素 

分 类 号：R711[医药卫生—妇产科学] R169[医药卫生—临床医学]