良性前列腺增生MR灌注成像的初步应用研究  

MR perfusion weighted imaging in the benign prostatic hyperplasia

作　　者：许建铭[1] 沈钧康[2] 张继斌[1] 李晓兵[1] 须同禄[1] 秦明明[1] 陆之安[2] 

机构地区：[1]苏州市第二人民医院放射科,江苏苏州215002 [2]苏州大学附属第二医院MRI室

出　　处：《中国医学影像技术》2004年第8期1175-1177,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的　探讨MR灌注成像在良性前列腺增生中的应用 ,评价血管内皮生长因子 (VEGF)和微血管密度 (MVD)与MR灌注成像各指标的相关性。方法　对临床诊断为良性前列腺增生 (BPH )的 42例患者和 3 0例健康志愿者进行MR灌注成像 (PWI) ,对BPH标本作免疫组化检测 ;分析病变灌注曲线最大线性斜率 (SSmax)、准T2弛豫率 (ΔR2 peak)与免疫组化结果 (VEGF、MVD)的相关性。结果　健康志愿者、BPH患者灌注曲线的最大线性斜率及准T2弛豫率分别为 0 .43 0±0 .0 11、2 .0 1± 0 .0 7和 3 3 .5± 3 .1、1.5± 0 .1(P <0 .0 5 )。结论　PWI可反映BPH患者MVD和VEGF表达程度 ,推测其血管生成情况。ObjectiveTo explore the preliminary application of perfusion weighted MR imaging (PWI) in benign prostatic hyperplasia (BPH), and to evaluate the correlation of PWI features with vascular endothelial growth factor (VEGF) and microvessel density (MVD). MethodsForty two consecutive patients who were diagnosed clinically of BPH and thirty healthy subjects were examined by PWI. MVD and VEGF were obtained with immuno histochemical methods. Some parameters of PWI, including the steepest slope of signal intensity time curve (SS max ) and ΔR2 *peak of lesions, were analyzed. Correlation analysis was used to determine the relation between the results of PWI and that of immuno histochemistry. ResultsIn the healty subjects, the SS max and ΔR2 *peak of perfusion curve was 0.430±0.011 and 2.01±0.07, respectively, while in BPH was 33.5±3.1, 1.5±0.1, respectively ( t =3.11, 2.23, P <0.05). ConclusionOn PWI, SS max and ΔR2 *peak can reflect MVD and VEGF express levels in BPH, implying the angiogenesis.

关 键 词：前列腺增生 磁共振成像 灌注 血管内皮生长因子 微血管密度 

分 类 号：R697.32[医药卫生—泌尿科学] R445.2[医药卫生—外科学]