多囊卵巢综合征患者血清、卵泡液中胰岛素样生长因子-Ⅰ水平研究  

Study on the serum and follicular fluid alterations of insulin like growth factor Ⅰ in patients with polycystic ovary syndrome

作　　者：徐雯[1] 王元佩[2] 赵采[2] 林婉秋[2] 刘越[2] 

机构地区：[1]福建医科大学省立临床医学院,350001 [2]福建省立医院,350001

出　　处：《福建医药杂志》2004年第4期113-114,共2页Fujian Medical Journal

摘　　要：目的　研究 PCOS患者血清、卵泡液中 IGF- 水平的改变。方法　对 11例 PCOS患者和 11例月经周期正常妇女进行早卵泡期末梢血和卵泡液 IGF- 水平测定 ,比较 IGF- 在 PCOS组与对照组研究对象之血清与卵泡液中水平的差异。结果　两组血清 IGF- 差异无统计学意义 ;PCOS组卵泡液中 IGF- 明显高于对照组 ;同组血清与卵泡液中的 IGF- 差别无统计学意义。结论　 IGF- 可能主要是通过血液渗透至卵泡液发挥作用 ,PCOS患者卵泡液 IGF- I改变可能和 PCOS的发生有关。Objective To investigate serum and follicular fluid alterations of IGF-Ⅰ in patients with PCOS.Methods IGF-Ⅰ was assayed in the follicular fluid from 11 patients with PCOS and 11 women with normal menstrual cycle.Peripheral serum was collected and assayed at the same time.Comparasion of IGF-Ⅰ in follicular fluid and peripheral serum,PCOS group and control group were conducted.Results Serum IGF-Ⅰ concentration in PCOS group was not different from that in the control women,but it was higher in follicular fluid in the PCOS women;follicular fluid IGF-Ⅰ concentration was not different from that in the serum level in both groups.Conclusion Follicular fluid IGF-Ⅰ may mainly come from serum,and IGF-Ⅰ in the micro-environment may play a role in the pathophysiology of PCOS.

关 键 词：卵泡液 PCOS 血清 IGF—I 多囊卵巢综合征患者 对照组 胰岛素样生长因子-I 水平 期末 结论 

分 类 号：R711.75[医药卫生—妇产科学] R725[医药卫生—临床医学]