冠心病与微生物慢性感染的血清学研究  

The Relation between Coronary Heart Disease and Chronic Infection of Microorganism

作　　者：田凤石[1] 胡大一[2] 孙新玲[1] 葛进[1] 马骏[3] 王娟[1] 徐莉[1] 赵明[1] 李田昌[2] 王金良[1] 

机构地区：[1]天津市公安医院,300050 [2]北京首都医科大学附属同仁医院 [3]天津医科大学

出　　处：《天津医药》2004年第9期554-556,共3页Tianjin Medical Journal

摘　　要：目的 :探讨巨细胞病毒 (CMV )、肺炎衣原体 (CP)和幽门螺杆菌 (HP)与冠心病 (CHD)的关系。方法 :应用荧光抗体法和ELISA法检测112例冠心病患者血清C_反应蛋白 (CRP)的水平及巨细胞病毒抗体 (CMVIgM)、肺炎衣原体抗体(CPIgG、CPIgM)和幽门螺杆菌抗体(HPIgG、HPIgM)的阳性率并与对照组比较。结果 :冠心病组与对照组比较CRP差别有统计学意义(t=15.100 ,P<0.01);CMVIgM、CPIgM差别无统计学意义(χ2分别为0.836和0,P>0.05) ;CPIgG、HPIgG和HPIgM差别有统计学意义(χ2 分别为6 590、6 372和7.830,P<0.05) ;经Logistic回归单因素和多因素分析 ,CPIgG、HPIgG与冠心病的有发病有关(均P<0.05)。结论Objective:To evaluate the relation between coronary heart disease and chronic infection of miˉcroorganism(CMV,CP,HP).Methods:C-reactive protein(CRP),Cytomegalovirus antibody(CMVIgM),Chamydia pneumonia antibodies(CPIgG,CPIgM)and Helicobacter pylori antibodies(HPIgG,HPIgM)in112cases with coronary artery disease and were examined by using fluorescence-antibody and ELISA techˉnique.Results:There was statistical significantly difference between coronary heart disease group and control group in CRP(t=15.100,P<0.01).There was no significant difference between two groups in CMVIgM(χ 2 =0.836,P>0.05)and in CPIgM(χ 2 =0,P>0.05).There were also significant differences in HPIgG,HPIgM and CPIgG(χ 2 =6.372,P=0.012,χ 2 =7.830,P<0.05,χ 2 =6.590,P<0.01respectively).However,there was significant relation between coronary heart disease and CPIgG and HPIgG(P<0.05respectively)by logistic regression analysis in single and multiple factors.Conclusions:Coronary heart disease is related to chronic infection of Chamydia pneumonia and Helicobacter pylori.

关 键 词：冠心病患者 慢性感染 对照组 血清学研究 肺炎衣原体抗体 CRP 巨细胞病毒(CMV) 结论 意义 差别 

分 类 号：R541.4[医药卫生—心血管疾病] R512[医药卫生—内科学]