川芎提取物穴位敷贴对脑缺血再灌注损伤大鼠t-PA与PAI活性的影响  

Effects of Acupoint Application with Extract of Rhizoma Ligustici Chuanxiong on Activities of t-PA and PAI in Rat with Cerebral IR Injury

作　　者：杨洁红 白海波[2] 万海同 蔡宇[2] 

机构地区：[1]浙江中医学院方剂教研室,杭州310053 [2]浙江大学,杭州310027

出　　处：《中国医药学报》2004年第9期526-528,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：浙江省自然科学基金资助项目 (No 3 0 14 98);浙江省中医药科研基金资助项目 (No 2 0 0 2C0 11)

摘　　要：目的 :观察川芎提取物穴位敷贴对组织型纤溶酶原激活物 (tissueplasminogenacti vator,t PA)与组织型纤溶酶原激活抑制物 (tissueplasminogenactivateinhibitor,PAI)活性的影响。方法 :采用四血管阻断法 (fourvesselsobstruct,4VO)制作大鼠脑缺血再灌注损伤模型 ,测定血浆t PA及PAI活性。结果 :川芎提取物穴位敷贴可使血浆中t PA活性升高 ,PAI活性下降 ,调节t PA与PAI的活性比例。结论 :川芎提取物穴位敷贴具有提高纤溶活性、溶栓消栓作用。Objective: To observe effects of acupoint application with extract of Rhizoma Ligustici Chuanxiong on activities of tissueplasminogen activator (t PA) and tissueplasminogen activate inhibitor (PAI) in rat with cerebral IR injury. Methods: The four vessels obstruct (4VO) were applied to make cerebral IR injury rat model. The activities of plasma t PA and PAI were measured. Result: Acupoint application with extract of Rhizoma Ligustici Chuanxiong could increase the activity of plasma t PA, decrease the activity of plasma PAI and regulate the activity proportion between t PA and PAI. Conclusion: Acupoint application with extract of Rhizoma Ligustici Chuanxiong could increase the activity of t-PA and could promote thrombolysis.

关 键 词：T-PA PAI 穴位敷贴 川芎 脑缺血再灌注损伤 提取物 活性 性比例 下降 调节 

分 类 号：R245[医药卫生—针灸推拿学]