嘿良冲剂对环磷酰胺所致小鼠白细胞总数、中性粒细胞减少的影响  

Dynamic Effect of Heiliangchongji (HLCJ) on Leukopenia and Neutropenia Introduced by Cyclophosphamide in Mice

作　　者：赵永娜[1] 张晓冬[1] 李斯文 李肇玖[1] 李顺英[1] 陈静[1] 

机构地区：[1]昆明医学院药学院,云南昆明650031 [2]云南省中医院肿瘤科,云南昆明650031

出　　处：《中国民族民间医药》2004年第5期295-297,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的 :观察嘿良冲剂高、中、低剂量在实验 4d、 8d、 12d、 16d对环磷酰胺 (CTX)所致小鼠白细胞总数 (WBC)、中性粒细胞 (N)减少的影响。方法 :每天腹腔注射CTX 10 0mg/kg ,连续 3天 ,诱发小鼠白细胞总数 (WBC)、中性粒细胞 (N)下降 ,在给予CTX的同时 ,应用不同剂量的嘿良冲剂进行治疗 ,动态观察嘿良冲剂对白细胞总数 (WBC)、中性粒细胞 (N)下降的影响。结果 :实验 4d ,嘿良冲剂各剂量组的WBC、N值与CTX模型组比较无明显变化 (P >0 0 5 ) ,实验 8d ,嘿良冲剂高、中剂量组的WBC值升高 (P <0 0 5 ) ,高、中、低剂量组N值升高 (P <0 0 1) ,实验 12d ,嘿良冲剂各剂量组的WBC、N值与CTX模型组比较明显升高 (P <0 0 1) ,实验 16d ,嘿良冲剂各剂量组、CTX模型组的WBC、N值回升 ,各组间比较差异无显著性意义 (P >0 0 5 )。结论 :实验 8d、实验 12d ,嘿良冲剂对环磷酰胺 (CTX)所致小鼠白细胞总数 (WBC)、中性粒细胞 (N)bjective:To investigate the protective action of HLCJ on the leukopenia and neutropenia induced by cytoxan(CTX)in mice. Method: Models of mice with leukopenia and neutropenia here were made by injecting with CTX(100 mg/kg)for 3 days,meanwhile,these mice were treated with HLCJ and the dynamic changes of 1eukocyte and neutrophil in these mice were observed.Results:HLCJ(32g/kg,16g/kg) administrated for 8 days could improve leukopenia and neutropenia induced by CTX in mice.Oral administration of HLCJ (32g/kg,16g/kg,8g/kg) for l2 days could increase the decreased number 0f 1eukocytes and neutrophil in CTX treated mice. Conclusion: HlCJ has significant protective effect on leukopenia and neutropenia induced by cytoxan in mice.

关 键 词：冲剂 WBC 白细胞总数 CTX 中性粒细胞 小鼠 环磷酰胺 实验 结论 显著性 

分 类 号：R283.6[医药卫生—中药学] R446[医药卫生—中医学]