卡介苗多糖核酸对COPD缓解期患者免疫功能的影响  

Effect of Amylose Nucleic Acid of BCG Vaccine on the Immunologic Function of COPD Patients in Remission Stage

作　　者：李昕辉[1] 刘永义[2] 

机构地区：[1]北华大学医学院附属医院呼吸内科,吉林省吉林市132011 [2]吉林省辽源市中心医院

出　　处：《中国全科医学》2004年第18期1337-1338,共2页Chinese General Practice

摘　　要：目的　探讨卡介苗多糖核酸对COPD缓解期患者免疫功能的影响。方法　将缓解期COPD患者随机分成两组 ,卡介苗治疗组和对照组 ,随访 1年 ,将治疗组和对照组呼吸道感染情况进行比较 ;同时将治疗组治疗前、后的T淋巴细胞亚群进行比较。结果　卡介苗治疗组发病次数减少。治疗前、后T淋巴细胞亚群CD+ 4 、CD+ 8水平及CD+ 4 /CD+ 8比值间差别均有显著性意义 (P <0 0 5 )。结论　卡介苗多糖核酸是一种良好的免疫调节剂。Objective To studied the effect of amylose nucleic acid of BCG Vaccine on the immunologic function of COPD patients in remission stage.Methods Allocating the COPD patients in remission stage into therapeutic group and control group randomly, following them one year, then comparing the infection situation of respiratory system, at the same time, comparing the patients' subpopulations of T lymphocytes in therapeutic group before and after therapy.Results The average infection times in therapeutic group's patients decreased. There was significant difference between CD + 4, CD + 8 level and CD + 4/CD + 8 ratio in subpopulations of T lymphocytes before and after therapy (P<0.05～0.01). Conclusion Amylose nucleic acid of BCG Vaccine is a kind of good immunoregulator.

关 键 词：卡介苗多糖核酸 治疗组 缓解期 患者 COPD 免疫功能 治疗前 结论 情况 水平 

分 类 号：R563[医药卫生—呼吸系统] R554.6[医药卫生—内科学]