α-Adducin基因和血管紧张素转换酶基因多态性与原发性高血压的关系  

α-Adducin and Angiotensin Converting Enzyme Polymorphisms in Essential Hypertension

作　　者：窦相峰[1] 孙凯[1] 黄晓红[1] 刘晓宁[1] 鞠振宇[1] 张红叶[1] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院中德分子医学实验室,北京市100037

出　　处：《中国循环杂志》2004年第4期286-289,共4页Chinese Circulation Journal

摘　　要：目的 :旨在探讨α adducin基因G460W和血管紧张素转换酶 (ACE)基因I/D多态性在国人中与原发性高血压的关系。方法 :2 3 4例原发性高血压患者 (高血压组 ) ,对每一高血压患者按性别、年龄 (± 3岁 )相同 1∶1匹配对照 (对照组 )。高血压组与对照组均进行基因分型 ,并通过心脑血管病标准问卷调查、血生化指标测定收集脑出血传统危险因素的信息。结果 :α adducin基因 460W等位基因频率在高血压组显著高于对照组 (基因型McNemar’s检验P =0 0 0 6)。多因素Logistic回归调整高血压传统危险因素后 ,α adducin基因 460W等位基因携带者与非 460W等位基因携带者相比 ,比值比(OR)为 1 5 5 ( 95 %CI,1 18～ 2 0 5 )。而高血压组和对照组ACE基因I/D多态性频率分布无差异 (基因型McNemar’s检验P =0 685 )。结论 :α adducin基因G460W多态性与原发性高血压显著相关 ,这种相关关系在调整了高血压其他危险因素后依然存在。关联关系的发现提示有必要对其与高血压的关系进行更为深入的探索 ,以期在高血压的治疗和预防中发挥作用。Objective:α-Adducin (ADD1) and angiotensin converting enzyme (ACE) polymorphisms have previously been implicated in hypertension and may influence renal sodium handling in Western population. We sought to examine the association the α-adducin G/W460 and ACE I/D polymorphisms and essential hypertension in Chinese people.Methods:All the subjects were genotyped for the ACE I/D and ADD1 G/W460 polymorphisms,and the two gene polymorphic frequencies were compared in patients with essential hypertension and individual age-and gender-matched normotensive control subjects. Information about prior exposure to various potential risk factors was also obtained.Results:A higher prevalence of W460 allele among patients with essential hypertension was noted. After adjustment for traditional risk factors of hypertension, the ADD1 460W allele was still significantly associated with ICH in Chinese (odds ratio,1.55;95%CI,1.18-2.05). No significant differences were found between patients with essential hypertension and normotensive control subjects in neither genotype nor allele frequencies of the ACE gene I/D polymorphism.Conclusion:The α-adducin gene G/W460 polymorphism is significantly associated with essential hypertension. This association does not appear to be mediated by established risk factors of essential hypertension.

关 键 词：原发性高血压 对照组 Α-ADDUCIN基因 危险因素 血管紧张素转换酶基因多态性 治疗 人中 等位基因频率 基因分型 发现 

分 类 号：R544.1[医药卫生—心血管疾病] R743.34[医药卫生—内科学]