银杏酸单体的抗菌活性研究  

Study on Anti-bacterium Activity of Ginkgolic Acids and Their Momomers

作　　者：杨小明[1] 朱伟[2] 陈钧[3] 钱之玉[4] 谢吉民[1] 

机构地区：[1]江苏大学化学化工学院,江苏镇江212013 [2]江苏大学医学技术学院,江苏镇江212001 [3]江苏大学生物与环境工程学院,江苏镇江212013 [4]中国药科大学,江苏南京210009

出　　处：《中药材》2004年第9期661-663,共3页Journal of Chinese Medicinal Materials

基　　金：江苏省教育厅自然科学研究项目 (0 1KJD3 10 0 0 3 )

摘　　要：目的 :从银杏外种皮中得到银杏酸混合物及三种单体 ,研究银杏酸的抗菌活性及其侧链与活性的关系。方法 :采用二倍稀释法测定了银杏酸混合物、各单体及水杨酸的最低抑菌浓度。结果 :银杏酸混合物对痤疮丙酸杆菌等G+菌具有良好的抑制作用。水杨酸无侧链 ,无抗菌活性。银杏酸侧链为C13∶0时抑菌效果最强。结论 :银杏酸的侧链是其产生抗菌活性的主要效应部位 。Objective: Ginkgolic acids and their three monomers were separated from ginkgo sarcotestas The anti bacterium activity of ginkgolic acids were tested The relation between the anti bacterium activity and side chain of ginkgolic acid were studied Method: The MIC of ginkgolic acids and their three monomers and salicylic acid were tested Results: Ginkgolic acid has strong inhibitive effect on G + bacterium Salicylic acid has no side chain, so no anti bacterical activity. When the length of gingkolic acid side chain is C13∶0, it has the strongest anti bacterical activity in three monomers Conclusion: The side chain of ginkgolic acid is the key functional group that possessed anti bacterical activity The length of Ginkgolic acid was the main effective factor of anti bacterical activity

关 键 词：银杏酸 抗菌活性 痤疮丙酸杆菌 效应部位 最低抑菌浓度 银杏外种皮 抑制作用 单体 侧链 混合物 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]