2，6-二氟苯胺及反应过程中产物的合成与应用  

The Synthesis And Application Of 2,6-Difluoroaniline And Its Reaction Process Products

作　　者：徐兆瑜[1] 

机构地区：[1]安徽省化工研究院,安徽合肥230041

出　　处：《精细化工原料及中间体》2004年第9期20-23,11,共5页Fine Chemical Industrial Raw Materials & Intermediates

摘　　要：介绍了2,6-二氟苯胺等的合成工艺路线。其合成所经历反应过程中间产物或衍生物,其中很多是重要的精细化工产品,同样富有升值和生产价值。开发这一产品及相关含氟化合物、可以形成一个产物链,视其市场情况,随时调整产品结构,生产出各种产品或化工中间体。具有一定的价格优势和市场竞争力。This paper describes the synthesis of 2,6-difluoroaniline.Which is an important intermediate for production of pharmaceuticals,pesticides and dyestuffS.The synthetic method:first the 2,6-difuoroben- zamide was got by the reaction of fluorinated of 2,6-difuorobenzo nitrile and hydrolysis.Then 2,6-di- fuoroanline was synthezed by the reaction of Hoffman rearrangement.The total yield was about 55.5%. The 2,6-difluorobenzonitrile is useful as an intermediate in the mannfacture of a variety chemical products including,for example,pharmaceuticals and agricultural chemicals,and it is manufactured in a halogen-ex- change by the action fluoride ion 2.6-dichlorobenzonitrile.The fluorine exchange is conducted under sub- stantially anhydrous conditions attemperature from 230℃ to 240℃ whem spary dried KF is used.Other- wise,in thesynthesis of 2,6-difluoroaniline reaction,there are intermedtate productswhich is an important raw materials used in production of pharmaceuticalintermediate and chemical products.The development of related will push on thedemand in 2,6-difluoroaniline,and superiority of cheaper price will makedomestic 2,6-difluoroaniline with strong market competitive power.

关 键 词：反应过程 2 6-二氟苯胺 合成工艺路线 中间产物 精细化工产品 衍生物 开发 升值 化工中间体 价格优势 

分 类 号：TQ246[化学工程—有机化工] TQ453.23