乙型肝炎肝硬化自发性细菌性腹膜炎患者T细胞亚群的研究  

Study of T Lymphocyte Subpopulations in Patients with Hepatitis B Liver Cirrhosis Spontaneous Bacterial Peritonitis

作　　者：王玲[1] 张才军[1] 李惠琴 谢蒲伶[1] 周曾全 邓学端[1] 

机构地区：[1]昆明医学院微生物学与免疫学教研室,昆明650031 [2]昆明市第三人民医院肝病研究室,昆明650041

出　　处：《昆明医学院学报》2004年第3期1-3,共3页Journal of Kunming Medical College

基　　金：昆明市科技局和昆明市卫生局科研基金资助课题

摘　　要：目的 :对 136例乙型肝炎肝硬化自发性细菌性腹膜炎患者的T淋巴细胞进行了研究 .方法 :采用间接荧光法检测了患者的T淋巴细胞亚群 (CD+ 3 ,CD+ 8和CD+ 4 /CD+ 8) .结果 :患者T淋巴细胞亚群表现为严重紊乱 ,与正常对照组比较 ,CD+ 3 T淋巴细胞明显下降 (P <0 0 1) ,CD+ 8T淋巴细胞明显升高 (P <0 0 1) ,导致CD+ 4 /CD+ 8明显降低 (P <0 0 1) .结论 :乙型肝炎肝硬化自发性细菌性腹膜炎患者的T淋巴细胞亚群紊乱 ,而使免疫功能紊乱 。Objective: To study T lymphocyte subpopulations in 136 cases with hepatitis B liver cirrhosis spontaneous bacterial peritonitis. Methods: It was detected by indirect fluorescence assay that T lymphocyte subpopulations (CD + 3,CD + 8 and CD + 4/CD + 8) of the patients. Results: T lymphocyte subpopulations of the patients were serious disorder. Compared with normal, CD + 3 T lymphocyte subpopulations was decreased significantly (P<0.01), CD + 8 was increased obviously (P<0.01), whereas CD + 4/CD + 8 was reduced obviously (P<0.01). Conclusion: T lymphocyte subpopulations were disorder in the patients with hepatitis B liver cirrhosis spontaneous bacterial Peritonitis. It results in disorder of immune functions. It has guiding significance for clinical therapy and prognostic judgement.

关 键 词：患者 自发性细菌性腹膜炎 乙型肝炎肝硬化 T淋巴细胞亚群 CD3^+ CD4^+/CD8^+ T细胞亚群 结论 指导 重要意义 

分 类 号：R512[医药卫生—内科学] R572.2[医药卫生—临床医学]