急性胰腺炎病因的病理学探讨  

Investigation of Pathogenesis in Acute Pancreatitis

作　　者：陈瑞芬[1] 赵敏[1] 王民[2] 王小平[1] 周以键[1] 王珏[1] 

机构地区：[1]首都医科大学病理解剖学教研室 [2]首都医科大学电镜室

出　　处：《首都医科大学学报》2004年第3期307-310,共4页Journal of Capital Medical University

摘　　要：胰胆管内逆行注射 5 .0 %牛磺胆酸钠溶液 ,建立大鼠急性出血坏死性胰腺炎 (AHNP)模型 ,通过光镜普通染色、PTH染色及电镜超微结构方法 ,对诱导AHNP后 5min至 6h胰腺的病变及微循环的形态学表现进行观察 ,以探讨胰腺炎的病因和发病机制。发现 :诱导AHNP后主要病变为 :胰腺组织出血、坏死 ,白色血栓、微血栓及混合血栓形成 ;并且随着诱导时间的延长病变加重。提示Observations of pathologic morphology were made at the early phase of acute hemorrhagic and necrotic pancreatitis(AHNP), to investigate pathogenesis of acute pancreatitis. AHNP was induced in rats(30, weight 300～350 g) by intraductal administration of 5% sodium taurocholate. The pathologic morphologic changes of pancreatic tissue were examined by light microscope by HE and PTH and electron microscope after induced 5 min to 6 h. Main pathological changes: hemorrhage and necrosis appear in pancreas, fibrin thrombus, white thrombus and mixed thrombus in small vessels. With the development of the disease pathological changes were aggravated. The result suggests: AHNP is associated with self-digestion and microcirculation disturbance.

关 键 词：AHNP 急性胰腺炎 病因 病理学 诱导 病变 微血栓 染色 白色 普通 

分 类 号：R657[医药卫生—外科学] R576[医药卫生—临床医学]