不对称转换拆分对羟基苯甘氨酸的研究  

Study on the Asymmetric Transformation Resolution of DL-p-Hydroxyphenylglycine

作　　者：史益强[1] 楼军军 王志祥[1] 

机构地区：[1]中国药科大学制药工程教研室,江苏南京210009 [2]浙江横店集团,浙江杭州310000

出　　处：《化工时刊》2004年第9期17-19,共3页Chemical Industry Times

摘　　要：以醋酸水溶液为溶剂 ,邻甲苯磺酸为拆分剂 ,水杨醛为消旋剂 ,用不对称转换拆分DL -对羟基苯甘氨酸为D -对羟基苯甘氨酸。考察了影响拆分收率和纯度的因素 ,其适宜条件 :醋酸水溶液的浓度为 97% ,诱导结晶的温度为10 0℃。The asymmetric transformation resolution of DL-p-hydroxyphenylglycine into its D-isomerswas studied by using o-toluene sulfonic acid as resolving agent、aqueous acetic acid as solvent and salicyladehyde as racemizing agent.The influences of process conditions on the productivity and purity were examined.The obtained optimum conditions were the concentration of aqueous acetic acid 97% and preferential crystallizing temperature 100℃.

关 键 词：对羟基苯甘氨酸 不对称转换 拆分 甲苯磺酸 醋酸水溶液 收率 溶剂 水杨醛 消旋 诱导结晶 

分 类 号：O625[理学—有机化学]