SARS肝功能损害与防治222例临床分析  

Prevention and treatment of liver injury in SARS patients-222 cases analysis

作　　者：铁振军[1] 张泰昌[1] 张枚[1] 崔志明[1] 田耕[1] 

机构地区：[1]首都医科大学宣武医院消化内科,100053

出　　处：《北京医学》2004年第5期318-320,共3页Beijing Medical Journal

摘　　要：目的　探讨SARS患者肝功能损害特点及药物对肝功能的影响。方法　 2 2 2例确诊患者分为普通型和重型。每型患者依ALT值分为正常、轻、中、重度组进行比较。将甘草酸单胺与谷胱甘肽分成单独治疗组和协同治疗组 ,观察其疗效。将应用头孢三代药物治疗的重型患者分别进行治疗前后肝功能测定值的比较 ,并同未应用头孢三代药物的重型患者肝功能损坏相比较。结果　 2 2 2例SARS患者肝功能总损害率为 6 1.7% ,其中轻度占35 .4 % ,中度占 2 1.7% ,重度占 4 .5 % ;重型患者发生肝损害比例与程度高于普通型。三组药物观察 ,治疗前后差别显著。应用头孢三代治疗者治疗后肝功能损害程度增加 ,与未应用头孢三代治疗的重型患者肝功能损坏比较 ,差异不显著。结论　SARS患者肝脏损害较重 ,重型患者发生比例与程度高于普通型。头孢三代药物可增加肝损害程度。Objective To study the characteristics and degrees of each type of liver injury in SARS.To study the effect of glycyrrhizin and Glutathion on liver injury,the effect of antihiotics on liver.Methods 222 cases were divided into common type and severe type.According to the amino-transferase (ALT) level,patients were divided into normal,mied,moderate,severe group.The effect of glutathion or glycyrrhizin alone and glutathion and glycyrrhizin combination were observed.Antibiotics were used to treat severe patients.Results 61.7% patients had liver injury.35.4% were mild,21.7% were moderate and 4.5% were severe.The liver injury patients in severe type group were more than that in normal group.The degree of liver injury was higher in antibiolic treatment patients.There was no significant difference in patients without antibiotic treatment.Conclusions The liver injury in SARS patients is prominent.Liver injury can occur in all SARS patients.There is a higher frequency of liver injury in severe patients.The antibiotics may compromise liver function.Glutathion and glycyrrhizin are useful in preventing liver injury.

关 键 词：SARS患者 重型 肝功能损害 头孢 药物 治疗前后 肝损害 单胺 谷胱甘肽 ALT 

分 类 号：R511.9[医药卫生—内科学]