流感疫苗安全性和免疫效果观察  

Observation on safety and immunogenicity of inactivated influenza vaccine

作　　者：徐天强[1] 李燕婷[1] 吴寰宇[1] 张爱香[1] 袁国娟[1] 孔利群[1] 顾宝柯[1] 

机构地区：[1]上海市疾病预防控制中心,上海200031

出　　处：《上海预防医学》2000年第9期432-434,共3页Shanghai Journal of Preventive Medicine

摘　　要：[目的 ]　评价流行性感冒疫苗 (防感灵TM)接种后的安全性和抗体阳转情况。 [方法 ]　采用随机和双盲法选择接种组和对照组 ,分别接种流感疫苗和伤寒Vi疫苗。接种后 3天内进行安全性观察。同时 ,免后 4个月时采集静脉血检测流感血凝抑制抗体的产生情况。 [结果 ]　接种组一般副反应率为 1.70 % ,全身副反应率为0 .6 4% ,与对照组差异无显著性。A1、A3、B型的血凝抑制抗体阳转率分别为 97.7%、99.2 %和 82 .9% ,接种组GMT均明显高于对照组。 [结论 ]　流感疫苗 (防感灵TM)安全性良好 。Objective] To evaluate the safety and immunogenicity of Flu vaccine (VAXIGRIP TM ). [Method]Samples were chosen by random and double-blind and divided into vaccination group and control group. The subjects of vaccination group and control group were vaccinated by Flu vaccine (VAXIGRIP TM ) and Typhoid vaccine(TYPHIM Vi TM ) separately. The safety of the two vaccines was observed within 3 days after vaccination. The HI antibody of Flu vaccine (VAXIGRIP TM ) was tested 4 months after vaccination. [Result] The rate of common side effect and serious side effect wrer 1.70% and 0.64% respectively. There was no significant difference between the two groups. The seroconversion rate of HI antibody for type A 1,type A 3 and type B influenza was 97.7%, 99.2%and 82.9% respectively. The GMT of vaccination group was much higher than that of the control group. [Conclusion] Flu vaccine (VAXIGRIP TM )is good in safety and immunogenicity.

关 键 词：流感疫苗 对照组 接种后 免疫效果观察 副反应 安全性 抗体 血凝抑制 采集 测流 

分 类 号：R186[医药卫生—流行病学]