三七总皂苷对痴呆大鼠模型学习记忆行为的影响及其机理探讨  

The Effects of PNS on Alzheimer's Disease Model of Mouse and Mechanism of the Effects

作　　者：郭长杰[1] 伍杰雄[2] 李若馨[3] 

机构地区：[1]北京大学深圳医院药剂科,深圳市518036 [2]中山大学医院管理处,广州市510080 [3]深圳市儿童医院儿童研究所,深圳市518036

出　　处：《中国药房》2004年第10期598-600,共3页China Pharmacy

摘　　要：目的 :观察三七总皂苷 (PNS)对鹅膏蕈氨酸 (IBA)所致痴呆大鼠模型的学习记忆行为及海马内乙酰胆碱 (ACh)含量的影响。方法 :将IBA注入大鼠Meynert基底核 (NBM )中建立痴呆模型 ,以生理盐水为阴性对照物 ,通过Morris水迷宫观察PNS对其学习记忆能力的改变 ,并用分光光度法测定海马内ACh的含量。结果 :PNS能够改善痴呆模型大鼠的学习记忆能力 ,提高海马内ACh的含量。结论 :PNS对痴呆大鼠的学习记忆能力降低有较好的治疗作用 ,提高海马内ACh含量可能为其作用机理之一。OBJECTIVE:To observe the effects of Panax notoginseng saponins(PNS)on learning and memory ability of ibotenic acid(IBA)-induced Alzheimer’s disease model of mouse and content of acetylcholine(ACh)in hippocamˉpus.METHODS:To develop the model by injecting into basalis magnocellularis with IBA.The models were treated with PNS and NS.Learning and memory ability were measured by Morris water maze and content of ACh in hippocampus by specˉtrophotometry.RESULTS:PNS can increase learning and memory ability and the content of ACh in hippocampus of model mouse.CONCLUSION:The reduction of learning and memory ability of mouse could be treated with PNS,and the increase of the content of ACh in hippocampus may be one of the mechanism of the effects.

关 键 词：三七总皂苷 痴呆 学习记忆 乙酰胆碱 

分 类 号：R965[医药卫生—药理学]