姜黄提取物对实验性动物高脂血症的防治作用研究  

Preventive and Therapeutic Effects of Extract of Curcuma on Experimental Hyperlipidemia Models

作　　者：杨俊卿[1] 周岐新[1] 李远宗[1] 

机构地区：[1]重庆医科大学药理教研室,重庆市400016

出　　处：《中国药房》2004年第10期600-602,共3页China Pharmacy

摘　　要：目的 :研究姜黄提取物对实验性动物高脂血症的预防和治疗作用。方法 :以正常大鼠和家兔为实验对象 ,以血清总胆固醇(TC)、甘油三酯 (TG)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)和LDL/HDL值为指标 ,观察姜黄提取物灌胃后对高脂血症大鼠的预防作用以及对高脂血症家兔的预防及治疗作用。结果 :大鼠预防给予不同剂量的姜黄提取物后 ,血脂呈剂量依赖性下降 ,TC、LDL降低 ,HDL升高 ,LDL/HDL值明显降低 ,且降脂作用强于阳性对照药洛伐他汀。家兔预防和治疗性给予姜黄提取物后 ,TC、TG、LDL和HDL呈剂量依赖性下降 ,LDL/HDL值降低不明显 ,其降脂作用弱于阳性对照药洛伐他汀。结论 :姜黄提取物可以显著降低大鼠和家兔的血脂水平 ,其对大鼠作用强于洛伐他汀 ,而对家兔则弱于洛伐他汀。OBJECTIVE:To evaluate the preventive and therapeutic effects of extract of Curcuma on experimental hyperˉlipidemia models in rats and rabbits.METHODS:Hyperlipidemia models of healthy rats and rabbits,fed on a forage containing cholesterol,fat and etc,were established.TG,TC,LDL,HDL and LDL/HDL in serum of animals were measured.RESULTS:The preventive administration of extract of Curcuma could significantly reduce the serum TC,LDL,LDL/HDL and increase serum HDL in hyperlipidemic rats in a dose-dependent manner.Its hypolipidemic action was stronger than that of positive contrast agent lovastatin.The serum levels of TC,TG,LDL and HDL not of LDL/HDL obviously decreased in hyperlipidemic rabbits after either preventive or therapeutic administration and its hypolipidemic action was weaker than that of positive conˉtrast agent lovastatin.CONCLUSION:Extract of Curcuma could obviouly reduce hyperlipidemic in rats and rabbits.Its action is stronger than that of lovastatin in rats,but weaker in rabbits.

关 键 词：姜黄提取物 高脂血症 洛伐他汀 预防和治疗 

分 类 号：R965[医药卫生—药理学]