大鼠周围神经端侧吻合后的功能评价  

Functional evaluation of peripheral nerve end-to-side anastomosis in rats

作　　者：李旭东[1] 季正伦[2] 何清濂[3] 

机构地区：[1]海军411医院整形外科,上海市东江湾路15号200081 [2]第二军医大学长海医院整形外科 [3]第二军医大学长征医院整形外科

出　　处：《中国康复医学杂志》2004年第7期521-522,共2页Chinese Journal of Rehabilitation Medicine

摘　　要：目的通过研究大鼠周围神经端侧吻合后腓总神经功能指数(PFI)和电生理指标,定量评价端侧吻合后再生纤维的功能。方法SD雄性大鼠30只,随机分为端侧吻合组和端端吻合组,端侧吻合组右侧建立胫腓神经端侧吻合模型,端端吻合组右侧建立腓神经端端吻合模型,术后2、3、5月,每组取5只测定PFI和运动神经传导速度及混合神经传导速度。结果端侧吻合后再生神经纤维功能恢复在3个月达到高峰,但效果不如端端吻合。结论端侧吻合可以作为神经修复的一种方法,但需慎重选择适应证。Objective: To study the peroneal nerve function index and electrophysiological test after peripheral nerve end-to-side anastomosis and evaluate quantificationally the function of collateral sprouting.Method:30 male SD rats were randomly divided into two groups(E-S and E-E group):In E-S group, the distal end of right peroneal nerve were end-to-side anastomosed to tibial nerve.In E-E group,right peroneal nerve were transected and sutured by end-to-end way.After 2,3,5month,PFI,MNCV and CNCV were observed.Result:Functional recovery could be found after end-to-side anastomosis and reached peak value at 3 month,but the effect is not as good as that of end-to-end anastomosis.Conclusion:The end-to-side anastomosis could be a method for the nerve repairing, however, the cases should be selected carefully.

关 键 词：周围神经端侧吻合 大鼠 电生理指标 腓总神经 运动神经传导速度 再生神经纤维 神经修复 结论 高峰 定量评价 

分 类 号：R651.3[医药卫生—外科学]