迅速减压对兔肺超微结构的影响  

Effects of rapid decompression on ultrastructure of lung in rabbits

作　　者：刘晓鹏[1] 肖华军[1] 笪冀平[2] 任力[2] 王萍[2] 闫汝泉[1] 齐燕松[1] 金忠正[1] 石强[1] 秦志峰[1] 付丽姗[1] 陈娟[1] 

机构地区：[1]北京空军航空医学研究所,100036 [2]空军总医院

出　　处：《解放军医学杂志》2004年第10期842-844,共3页Medical Journal of Chinese People's Liberation Army

基　　金：空军科学研究基金资助课题 (编号kj0 2 2 32 )

摘　　要：目的　研究迅速减压对兔肺超微结构的影响。方法　将 30只新西兰白兔随机分为慢上升减压组和迅速减压组 ,用透射电镜观察兔肺超微结构的变化。结果　迅速减压组兔肺Ⅰ型及Ⅱ型肺泡细胞膜结构不清 ,细胞间连接松散 ,Ⅱ型肺泡细胞内发现肿胀的线粒体及扩张的粗面内质网 ,肺泡壁毛细血管扩张充血 ,血管内皮细胞肿胀 ,通透性增加。当减压峰值大于 9 8kPa(10 0 0mmH2 O)时变化更为明显。结论　迅速减压能引起肺脏损伤 ,减压峰值越大 ,结构破坏就越重。Objective To study the effect of rapid decompression on ultrastructure of the lung in rabbits. Methods Thirty healthy New-Zealand rabbits were randomly divided into low decompression group and rapid decompression group. The pulmonary ultrastructure of rabbits was observed with transmission electron microscope (TEM). Results In rabbits of the rapid decompression group, a number of pathological changes were found, such as disruption of cell membrane structure of types Ⅰ and Ⅱ alveolar cells, loosening of intercellular linkage, edematous mitochondria, expanded rough endoplasmic reticulum, engorged capillary of alveolar wall, edematous capillary endothelium cells, and increased capillary permeability. These changes became especially obvious when the decompression peak value was above 9.8 kPa. Conclusion Rapid decompression could inflict injury to the lung, which was aggravated with the increase of the decompression peak value.

关 键 词：迅速减压 肺 超微结构 兔 

分 类 号：R852.12[医药卫生—航空、航天与航海医学]