血液透析患者C-反应蛋白与心血管疾病的关系  

Relationship between CRP and cardiovascular disease in hemodialysis patients

作　　者：卞维静[1] 张凌[1] 杜学海[1] 时庆新[2] 

机构地区：[1]中日友好医院肾病中心,北京100029 [2]中日友好医检验科,北京100029

出　　处：《中日友好医院学报》2004年第5期262-264,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的 :探讨血液透析患者的慢性炎症与心血管疾病的关系。方法 :对 6 4例稳定的血液透析患者进行统计分析慢性炎症的标志物 血C 反应蛋白 (C reactiveprotein ,CRP)和心血管疾病 (心肌梗死、心绞痛及心力衰竭 )的关系。结果 :6 4例患者中有 2 8.1% ( 18/ 6 4 )的患者CRP超过正常值 (正常值为 <5mg/L) ,平均血CRP12 .6 1mg/L± 4 .81mg/L( 5 .90mg/L～ 2 1.4mg/L)。其中有心血管疾病患者 2 7例 ,无心血管疾病患者 37例。心血管疾病组的CRP( 7.79mg/L± 6 .6 1mg/L)明显高于无心血管疾病组 ( 2 .14mg/L± 3.5 9mg/L) (P <0 .0 1)。多元Logistic逐步回归分析证实 :CRP是心血管疾病的独立致病因素。 结论 :血液透析治疗的患者确实存在慢性炎症 ;Objective:To identify the relationship between chronic inflammation state and cardiovascular diseases in hemodialysis patients.Methods:C-reactive protein(CRP) was measured as the marker of chronic inflammation. The relationship between CRP and cardiovascular diseases were analysed in 64 stable hemodialysis patients without clinical appearance of inflamation.Results:27 patients had cardiovascular diseases(myocardial infarction, angina pectoris and chronic heart failure).Patients with cardiovascular diseases had significantly higher CRP(7.79 mg/L±6.61 mg/L vs 2.14 mg/L±3.59 mg/L, P <0.01) than patients without cardiovascular diseases.Multivariate regression analysis demonstrated that CRP were independent predictors of cardiovascular diseases.Conclusion:The results showed the presence of chronic inflammation in hemodialysis patients. Chronic inflammation had the link with cardiovascular diseases.

关 键 词：心血管疾病 CRP 血液透析患者 慢性炎症 C-反应蛋白 治疗 正常值 结论 多元 目的 

分 类 号：R692.5[医药卫生—泌尿科学]