中国甘肃地区汉族白血病易感性与HLA-Ⅰ类抗原之间的相关性(英文)  

HLA class-Ⅰ antigens in Gansu Chinese Han nationality with leukemia

作　　者：赵丽[1] 周兰霞[1] 曹海霞 

机构地区：[1]兰州医学院第一附属医院中心实验室,兰州730000 [2]青海妇女儿童医院,西宁810007

出　　处：《中国免疫学杂志》2004年第10期693-695,共3页Chinese Journal of Immunology

基　　金：甘肃省自然科学基金暨中青年基金项目 (YS0 0 0 1 A2 3 0 2 0 )

摘　　要：目的 :探讨中国甘肃地区汉族白血病易感性与HLA Ⅰ类抗原之间的相关性 ,找出白血病的易感基因。方法 :采用特异性寡核苷酸探针杂交 (PCR SSO)法 ,初步对 4 3名白血病病人和 6 6名健康对照进行了HLA Ⅰ抗原分型。结果 :经过SSPS 10 0统计软件分析 ,中国甘肃地区汉族白血病患者HLA A 0 1和HLA A 11基因的统计结果分别为X2 =6 35 0 ,P =0 0 2 8、X2 =5 5 74 ,P =0 0 18。显示相关性。结论 :中国甘肃地区汉族人群中HLA A 0 1和HLA AObjective:Host genetic factors are known to contribute to disease susceptibility.They may also be important in defining the pattern of disease presentation and progression,as well as its overall prognosis.However,no consistent HLA class-Ⅰ associations have been established in leukemia by PCR/SSOP in Gansu Chinese Han.Such studies have been reported in other counties,with conflicting results.This is the first PCR-based HLA class-Ⅰ association study in northwestern Chinese Han nationality leukemia.Methods:Compared HLA class-Ⅰ in 43 Chinese leukemia patients and 66 healthy Chinese controls as determined by polymerase chain reaction and sequence-specific olignucletide probe hybridization(PCR/SSO) DNA analysis.Results:Compared with normal control,the frequency of HLA-A 01、A 11 were significantly increased in leukemia group.Conclusion:The present findings imply that HLA-associated genetic factors influence the risk for the development of leukemia.

关 键 词：HEA-Ⅰ类抗原 白血病易感性 PCR/SSO 中国甘肃地区汉族 

分 类 号：R392.13[医药卫生—免疫学]