SARS患者血清IL-8、IL-12和TGF-β1的检测及意义  

Detection of the levels of the IL-8、IL-12 and TGF-β1 in serum of the patienes with the SARS-coronavirus infection and its clinical significance

作　　者：江振友[1] 高阳[2] 方丹云[3] 周经姣[3] 晏辉钧[3] 江丽芳[3] 

机构地区：[1]暨南大学医学院微生物学与免疫学教研室,广州510632 [2]广州市疾病预防控制中心,广州510080 [3]中山大学中山医学院微生物学教研室,广州510089

出　　处：《中国免疫学杂志》2004年第10期717-719,共3页Chinese Journal of Immunology

基　　金：国家自然科学基金"防治SARS紧急研究"项目 (3 0 3 40 0 13 );广东省自然科学基金资助项目

摘　　要：目的 :探讨SARS患者血清IL 8、IL 12和TGF β1在SARS冠状病毒感染致病中的作用。 方法 :应用酶联免疫吸附法 (ELISA)测定广州地区 2 8例SARS冠状病毒感染患者双份血清IL 8、IL 12和TGF β1的水平。实验数据采用两样本均数t检验法。结果 :2 8例SARS冠状病毒感染者血清IL 8水平、病程第 2周IL 12水平比正常健康对照组明显降低 (P <0 0 5 )。SARS冠状病毒感染者血清TGF β1水平与对照组比较无明显差异 (P >0 0 5 )。 结论 :IL 8和ILObjective:To study the effect of interleukin-8(IL-8),interleukin-12(IL-12)and transforming growth factor-beta 1(TGF-β1) in the immune pathogenesis of SARS-coronavirus infection.Methods:The serum levels of IL-8、IL-12 and TGF-β1 were measured with enzyme linked immunosorbent assay (ELISA) method in 28 cases of the patients with the SARS-coronavirus infection in Guangzhou district. The results were treated with t -test of two sample means.Results:The serum levels of IL-8 in patients with the SARS-coronavirus infection were much lower than that of healthy controls ( P <0.05); The serum levels of IL-12 in patients were much lower than that of healthy controls on second weeks periods of patients with SARS ( P <0.05);The serum levels of TGF-β1 in patients with the SARS-coronavirus infection showed no remarkable change than that of healthy controls ( P >0.05).Conclusion:The data suggest that the IL-8 and IL-12 play an important role in SARS-CoV cell immunity.

关 键 词：IL-12 血清IL-8 TGF-Β1 SARS冠状病毒 SARS患者 对照组 致病 冠状病毒感染 免疫过程 广州地区 

分 类 号：R563[医药卫生—呼吸系统] R692[医药卫生—内科学]