冠心病并发糖尿病QT间期及离散度变化的临床意义  

Clinical significance of QT interval and dispersion in coronary heart disease patients combined with diabetes meilitus

作　　者：李绍生[1] 谢虎 杨杰[3] 李兰荪[3] 

机构地区：[1]第四军医大学西京医院心内科,西安710032 [2]陕西省榆林市第二人民医院心内科 [3]解放军第230医院内三科

出　　处：《陕西医学杂志》2004年第10期909-911,共3页Shaanxi Medical Journal

摘　　要：目的 :了解糖尿病 ( DM)和冠心病 ( CHD)病人的 QTc和 QTd变化 ,为预测心血管事件的发生提供依据。方法 :将 1 30例 DM、CHD病人分为 CHD组 ( G1) 5 3例、DM组( G2 ) 47例、CHD合并 DM组 ( G3) 30例 ,对比 QTc和 QTd的变化及其与 DM和 CHD的相关性。结果 :G3组病人的 QTc和 QTd较 G1、G2 组明显延长 ( P<0 .0 1 ) ,相关分析结果显示QTd与 QTc明显相关 ( r=0 .2 5 2 ,P<0 .0 1 ) ,DM或 CHD病人的 QTc与是否合并 CHD或DM独立相关 ( r=0 .368和 0 .336,P<0 .0 5 )。结论 :DM对心肌电活动的影响与心肌缺血引起的相近 ,二者合并出现后加重了心肌电活动的不稳定性。Objective:Patients with DM or CHD had higher mean adjusted values of QTc and QTc dispersion which can predict cardic and vascular affairs. Methods: A case-case control study was designed. 130 patients were assigned into three groups: CHD group(G 1 n=53),DM group(G 2 n=47),CHD and DM group(G 3 n=30).Change of QTc and QTd were compared between the groups, the relationship between them was analysed. Results:G 3 had a higher QTc and QTc dispersion than G 1 and G 2(P<0.01).Regression analysis suggested that QTd and QTc duration were significantly correlated (r=0.252, P<0.01), QTc was independently associated with DM or CHD in CHD or DM patients(r=0.368 and 0.336 P<0.0 5).Conclusion: There was an equal effect on electronic action of myocardium in patients with DM compared with CHD, and a higher injury if they existed at the same time.

关 键 词：CHD DM 病人 冠心病 QT间期 肌电活动 糖尿病 合并 结论 变化 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]