益脉降压流浸膏对老年原发性高血压患者肾上腺髓质素、内皮素及血管紧张素Ⅱ的影响(英文)  

Impact of yimai jiangya fluid extract on adrenomedullin,endothelin and angiote nsinⅡof the elders with essential hypertension

作　　者：段学忠[1] 孙西庆[2] 蔡新吉[1] 张燕[1] 

机构地区：[1]解放军济南军区总医院中医科,山东省济南市250031 [2]山东中医药大学附属医院内科,山东省济南市250011

出　　处：《中国临床康复》2004年第30期6808-6810,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:原发性高血压患者血浆肾上腺髓质素(adrenomedullin,ADM)、内皮素、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)水平升高,但抗高血压治疗对其影响尚未十分了解。目的:探讨益脉降压流浸膏对老年气虚血瘀证型Ⅱ期原发性高血压患者血管活性物质的影响。设计:以诊断为依据,随机对照试验。地点、对象和方法:病例来源于济南军区总医院及山东中医药大学附属医院,实验在山东中医药大学附属医院中心实验室进行。入选的60例患者均系1999-03/09期间观察的患者,其中住院患者36例,门诊患者24例。纳入标准:年龄≥60岁,符合1993年WHO/ISH高血压诊断标准,排除标准:排除继发性高血压、糖尿病、冠心病、肝肾疾病及内分泌疾病,剔除Ⅰ期和Ⅲ期原发性高血压,同时按中国中西医结合研究会制定的中医虚证辨证标准及血瘀证诊断标准辨证为气虚血瘀证型者,按随机数字法分为两组。治疗组(益脉降压流浸膏治疗)30例,男17例,女13例;对照组(卡托普利治疗)30例,男18例,女12例。另设健康对照组25例,为同期来济南军区总医院的健康体检者,并为自愿受试者,男14例,女11例。采用放射免疫法测定60例老年气虚血瘀证型Ⅱ期原发性高血压患者治疗前后及25例老年健康人(健康对照组)血浆ADM、内皮素、AngⅡ水平进行比较。结果:治疗组和对照组患者治疗前血?BACKGROUND:Concentrations of adrenomedullin(ADM),endothelin and angiotensin Ⅱ (Ang Ⅱ) were found increased in patients with essential hypertension,however t he influence of anti hypertension treatment on them had still been uncertain. OBJECTIVE:To explore the influence of yimai jiangya fluid extract on adrenome dullin,endothelin and Ang Ⅱof the elders with stage Ⅱessential hypertension o f qi deficiency and blood stasis. DESIGN:Clinical randomized controlled trial. SETTING,PARTICIPANTS and METHODS:Patients were all from Jinan Military General Hospital and Affiliated Hospital of Shandong University of Traditional Chinese Medicine,and the experiment was performed at the Center Laboratory.Of all sixty patients from March to September 1999,thirty six cases were in patients and th e other 24 were outpatients.Enrolling criteria:Patients were not less than 60 ye ars old and accorded with the International Society of Hypertension(ISH) diagnos tic standard for hypertension by WHO in 1993.Excluding criteria:Patients with se condary hypertension,diabetes mellitus,coronary disease,liver and kidney disease s and endocrine disorders,and stageⅠand Ⅲessential hypertension were excluded; meanwhile qi deficiency and blood stasis were confirmed according to the syndrom e differentiation criteria by Chinese Association of the Integration of Traditio nal and Western Medicine.Sixty cases were randomly divided as treatment group(TG ) subjected to yimai jiangya fluid extract(n=30,consists of 17 males and 13 fema les) and control group(CG) treated with capital(n=30 consists of 18 males and 12 females).Twenty five healthy volunteers consisting of 14 males and 11 females from Jinan Military General Hospital made up healthy control group(HC).The conte nts of plasma ADM,endothelin and Ang Ⅱof patients in TG and CG were determined by radioimmunoassay after treatment and compared with those of HC. RESULTS:Mean contents of ADM,endothelin and AngⅡin TG and CG were(67.8±16.1) ng/L,(72.1±10.4) μg/L,and(172.5±4

关 键 词：高血压/中药疗法 膏剂 气虚 血瘀 肾上腺髓质素/代谢 内皮素/代谢 血管紧张素Ⅱ/代谢 

分 类 号：R544.1[医药卫生—心血管疾病]