IL-12及其他细胞因子与反复呼吸道感染的相关性研究  

Correlative study between IL-12 and recurrent respiratory tract infection

作　　者：王吉安[1] 孙秀玲[2] 

机构地区：[1]临沂市人民医院儿科,山东临沂276003 [2]临沂医学专科学校生化教研室,山东临沂276002

出　　处：《小儿急救医学》2004年第5期308-310,共3页Pediatric Emergency Medicine

摘　　要：目的　探讨婴幼儿反复呼吸道感染 (recurrentrespiratorytractinfection ,RRI)的发病因素 ,为积极预防及早期免疫调理治疗RRI找出一条新的有效途径。方法　抽取 111例正常出生的新生儿脐血 ,检测白细胞介素 12 (IL 12 )等细胞因子水平作为脐血组 ;随后进行追踪随访观察 ,于 18个月时再次抽取静脉血 ,检测IL 12及其他细胞因子水平 ,其中有 18例符合反复呼吸道感染的诊断标准 ,作为RRI组 ,其余为健康组。分别对脐血健康组、脐血RRI组、18个月健康组、18个月RRI组进行比较。结果　RRI组血清IL 12、IFN γ、IL 2细胞因子水平均低于健康组 (P <0 0 0 1)。结论　反复呼吸道感染患儿除一些外在的发病诱因外 ,其自身先天免疫功能低下 。Objective To explore the pathogenic factors of recurrent respiratory tract infection(RRI)so as to find out an effective way of preventing and treating the disease.Methods In 111 cases of new-born babies with normal birth,the cord blood was with drawn and a follow-up survey was made on then.After a period of 18 months,the venous blood of the babies was again withdrawn,with 18 cases diagnosed of RRI.The levels of IL-12?IFN-γ?IL-2?IL-6?and IL-8 in the venous blood(18?months)and the cord blood were detected respectively.Results In comparison there were noticeable differences levels of IL-12?IFN-γ and IL-2(P<0.001)in between the health cord group and the health group(P<0.001).Conclusion The babies with recurrent respiratory tract infection showed a lower immune function besides some external predisposing facators and especially the lower cellular immune functon in them was the important internal cause of the diseases onset.

关 键 词：RRI IL-12 反复呼吸道感染 细胞因子水平 健康 脐血 相关性研究 结论 免疫调理 有效途径 

分 类 号：R725.6[医药卫生—儿科]