水飞蓟素纳米粒载体材料与制备方法的初步筛选  

Preliminary study on materials and preparation of silymarin-loaded nanoparticles

作　　者：何军[1,2] 奉建芳[1] 庞家忠[3] 陆伟根[1] 侯世祥[2] 

机构地区：[1]上海医药工业研究院药物制剂部 [2]四川大学华西药学院,成都,610041 [3]广西中医学院

出　　处：《中南药学》2004年第5期259-261,共3页Central South Pharmacy

基　　金：国家"863"计划项目(2001AA218011);上海市纳米科技与产业发展促进中心项目(0143nm063)

摘　　要：目的 对水飞蓟素纳米粒载体材料和制备方法进行了初步筛选。方法 以平均粒径、包封率、载药量和表面形态作为评价指标,考察了水飞蓟素纳米粒载体材料和制备方法。结果 固体脂质纳米粒(SLN)具有较高的包封率,纳米粒呈片状;乳酸/乙醇酸共聚物(PLGA)纳米粒粒径分布较均匀;纳米脂质体形成较少。结论 选择山榆酸甘油酯作为制备水飞蓟素纳米粒的载体材料,采用高压乳匀法制备水飞蓟素SLN是较为理想的方法。OBJECTIVE To study the materials and preparation of silymarin-loaded nanoparticles preliminarily. METHODS Materials and preparation of silymarin-loaded nanoparticles were selected by mean diameter, entrapment efficiency, drug loading, and morphology. RESULTS Solid lipid nanoparticles had better entrapment efficiency and it was sheet-shaped. PLGA nanoparticles had narrow size distribution. However, nanoliposomes was hardly formed. CONCLUSIONS Compritol 888 ATO was a good material for preparing silymarin-loaded nanoparticles, and high pressure homogenization may be used to prepare the silymarin-loaded SLN.

关 键 词：固体脂质纳米粒 水飞蓟素 山榆酸甘油酯 高压乳匀法 

分 类 号：TQ460[化学工程—制药化工]